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Selective TASK-1 inhibitor with a defined structure–activity relationship reduces cancer cell proliferation and viability
Arévalo, Bárbara; Bedoya, Mauricio; Kiper, Aytug K.; Vergara, Fernando; Ramírez, David; Mazola, Yuliet; Bustos, Daniel; Zúñiga, Rafael; Cikutovic, Rocio; Cayo, Angel; Rinné, Susanne; Ramirez-Apan, M. Teresa; Sepúlveda, Francisco V.; Cerda, Oscar; López-Collazo, Eduardo; Decher, Niels; Zúñiga, Leandro; Gutiérrez, Margarita; González, Wendy (2021)Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. These compounds ...
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Synthesis of pyrazolo-fused 4-azafluorenones in an ionic liquid. mechanistic insights by joint studies using dft analysis and mass spectrometry
Polo, Efraín; Arce-Parada, Valentina; López-Cortés, Xaviera A.; Sánchez-Márquez, Jesús; Morales-Bayuelo, Alejandro; Forero-Doria, Oscar; Gutiérrez, Margarita (2019)A series of pyrazolo-fused 4-azafluorenones (indeno[1,2-b]pyrazolo[4,3-e]pyridines, IPP) were synthesized via the three-component reaction between arylaldehydes, 3-methyl-1H-pyrazol5-amine and 1,3-indanedione in an ionic ...