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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
Ortiz-Manrique, Macarena; Valenzuela, Rodrigo; Rincón-Cervera, Miguel Ángel; Echeverría, Francisca; Barrera, Cynthia; Espinosa, Alejandra; Hernández-Rodas, María Catalina; Valenzuela, Alfonso; Videla, Luis A. (2018)Objectives: Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, ...
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Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration
Ortiz, Macarena; Soto-Alarcón, Sandra A.; Orellana, Paula; Espinosa, Alejandra; Campos, Cristian; López-Arana, Sandra; Rincón-Cervera, Miguel Ángel; Illesca, Paola; Valenzuela, Rodrigo; Videla, Luis A. (2020)Objective: Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative stress and mitochondrial dysfunction, which can be eluded by the co-administration of the lipid metabolism modulator docosahexaenoic ...