• Dermal collagen stabilization by polyphenols and spray drying as an encapsulation strategy 

    Añazco-Oyarzún, Carolina; Rojas, Armando ORCID; González-Bonet, Ileana; Castro, Maite A.; Robert, Paz; Oyarzun-Ampuero, Felipe (2018)
    Collagen, the most abundant component in mammalian tissues, has a crucial impact at skin level. Both promotion and maintenance of cross-linked collagen at the skin are critical to sustain the functionality and appearance ...

  • Exploring the interplay between polyphenols and lysyl oxidase enzymes for maintaining extracellular matrix homeostasis 

    Añazco-Oyarzún, Carolina; Riedelsberger, Janin; Vega-Montoto, Lorenzo; Rojas, Armando ORCID (2023)
    Collagen, the most abundant structural protein found in mammals, plays a vital role as a constituent of the extracellular matrix (ECM) that surrounds cells. Collagen fibrils are strengthened through the formation of ...

  • Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer 

    Rojas, Armando ORCID; Añazco-Oyarzún, Carolina; González-Bonet, Ileana; Araya, Paulina (2018)
    A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...

  • Gastric tumor microenvironment 

    Rojas, Armando ORCID; Araya, Paulina; González-Bonet, Ileana; Morales, Erik (2020)
    A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided ...

  • Lysyl oxidase isoforms in gastric cancer 

    Delgado-López, Fernando; Araya, Paulina; González-Bonet, Ileana; Morales-Mejías, Erik; Pérez-Castro, Ramón; Romero, Jacqueline; Rojas, Armando ORCID; Añazco-Oyarzún, Carolina (2016)
    Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...

  • Lysyl oxidase like-2 crosslinks collagen IV of glomerular basement membrane 

    Añazco-Oyarzún, Carolina; López-Jiménez, Alberto J.; Rafi, Mohamed; Vega-Montoto, Lorenzo; Zhang, Ming-Zhi; Hudson, Billy G.; Vanacore, Roberto M. (2016)
    The 7S dodecamer is recognized as an important structural crosslinking domain of collagen IV networks that provide mechanical stability to basement membranes, a specialized form of extracellular matrix essential for the ...