Listar Artículos Científicos por autor 

Listar Artículos Científicos por autor

Mostrando publicaciones 1-8 de 8

  • Assessment of e-social activity in psychiatric patients 

    Bonilla-Escribano, Pablo; Ramírez, David; Sedano-Capdevila, Alba; Campaña-Montes, Juan J.; Baca-García, Enrique; Courtet, Philippe; Artés-Rodríguez, Antonio (2019)
    This paper introduces a novel method to assess the social activity maintained by psychiatric patients using information and communication technologies. In particular, we model the daily usage patterns of phone calls and ...

  • Conotoxins as tools to understand the physiological function of voltage-gated calcium (CaV) channels 

    Ramírez, David; Gonzalez, Wendy; Fissore, Rafael A.; Carvacho-Contreras, Ingrid (2017)
    Voltage-gated calcium (CaV) channels are widely expressed and are essential for the completion of multiple physiological processes. Close regulation of their activity by specific inhibitors and agonists become fundamental ...

  • Elucidating the structural basis of the intracellular pH sensing mechanism of TASK-2 K2P channels 

    Bustos, Daniel; Bedoya, Mauricio; Ramírez, David; Concha, Guierdy; Zúñiga, Leandro; Decher, Niels; Hernández-Rodríguez, Erix W.; Sepúlveda, Francisco V.; Martínez, Leandro; González, Wendy (2020)
    Two-pore domain potassium (K2P) channels maintain the cell’s background conductance by stabilizing the resting membrane potential. They assemble as dimers possessing four transmembrane helices in each subunit. K2P channels ...

  • Iridoid esters from Valeriana pavonii Poepp. & Endl. as GABAA modulators: structural insights in their binding mode and structure-activity relationship 

    Giraldo, Sara E.; Bedoya, Mauricio; Peña-Varas, Carlos; Santana, Paula A; Bazzocchi, Isabel L.; Jiménez, Ignacio A.; Marder, Mariel; Vergel, Nadezdha E.; Guerrero, Mario F.; Ramírez, David (2023)
    Context: Valeriana pavonii Poepp. & Endl. (Caprifoliaceae), is a plant used in traditional medicine as a tranquilizer in Colombia. Valerian extracts have been widely used since ancient times for their sedative and anxiolytic ...

  • New drug design avenues targeting alzheimer’s disease by pharmacoinformatics-aided tools 

    Arrué, Lily; Cigna-Méndez, Alexandra; Barbosa, Tábata; Borrego-Muñoz, Paola; Struve-Villalobos, Silvia; Oviedo, Victoria; Martínez-García, Claudia; Sepúlveda-Lara, Alexis; Millán, Natalia; Márquez Montesinos, José C. E; Muñoz, Juana; Santana, Paula A; Peña-Varas, Carlos; Barreto, George E; González, Janneth; Ramírez, David; Arrué (2022)
    Neurodegenerative diseases (NDD) have been of great interest to scientists for a long time due to their multifactorial character. Among these pathologies, Alzheimer’s disease (AD) is of special relevance, and despite the ...

  • Selective TASK-1 inhibitor with a defined structure–activity relationship reduces cancer cell proliferation and viability 

    Arévalo, Bárbara; Bedoya, Mauricio; Kiper, Aytug K.; Vergara, Fernando; Ramírez, David; Mazola, Yuliet; Bustos, Daniel; Zúñiga, Rafael; Cikutovic, Rocio; Cayo, Angel; Rinné, Susanne; Ramirez-Apan, M. Teresa; Sepúlveda, Francisco V.; Cerda, Oscar; López-Collazo, Eduardo; Decher, Niels; Zúñiga, Leandro; Gutiérrez, Margarita; González, Wendy (2021)
    Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. These compounds ...

  • Selective TASK-1 inhibitor with a defined structure–activity relationship reduces cancer cell proliferation and viability 

    Arévalo, Bárbara; Bedoya, Mauricio; Kiper, Aytug K.; Vergara, Fernando; Ramírez, David; Mazola, Yuliet; Bustos, Daniel; Zúñiga, Rafael; Cikutovic, Rocio; Cayo, Angel; Rinné, Susanne; Ramirez-Apan, M. Teresa; Sepúlveda, Francisco V.; Cerda, Oscar; López-Collazo, Eduardo; Decher, Niels; Zúñiga, Leandro; Gutierrez, Margarita; González, Wendy (2022)
    Chemical structures of selective blockers of TASK channels contain aromatic groups and amide bonds. Using this rationale, we designed and synthesized a series of compounds based on 3-benzamidobenzoic acid. These compounds ...

  • Structure/activity analysis of TASK-3 channel antagonists based on a 5,6,7,8 tetrahydropyrido[4,3-d]pyrimidine 

    Ramírez, David; Bedoya, Mauricio; Kiper, Aytug K.; Rinné, Susanne; Morales-Navarro, Samuel; Hernández-Rodríguez, Erix W.; Sepúlveda, Francisco V.; Drecher, Niels; González, Wendy (2019)
    TASK-3 potassium (K+) channels are highly expressed in the central nervous system, regulating the membrane potential of excitable cells. TASK-3 is involved in neurotransmitter action and has been identified as an oncogenic ...