Buscar
Mostrando publicaciones 1-8 de 8
Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
(2016)
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...
NF-κB signaling pathway as target for antiplatelet activity
(2016)
In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes.
Although platelets lack a nucleus, a number of functional ...
Role of multiligand/RAGE axis in platelet activation
(2014)
In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...
The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
(2013)
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...
Dietary advanced glycation end products and their role in health and disease
(2015)
Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and ...
Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
(2018)
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
Dietary AGEs as exogenous boosters of inflammation
(2021)
Most chronic modern non-transmissible diseases seem to begin as the result of low-grade inflammation extending over prolonged periods of time. The importance of diet as a source of many pro-inflammatory compounds that could ...
Polymorphisms −374 T/A and −429 T/C of the receptor for advanced glycation end-products (RAGE) and serum levels of RAGE (sRAGE) are not associated with metabolic syndrome
(2023)
RAGE is a multi-ligand transmembrane glycoprotein that promotes biological signals associated with inflammatory responses and degenerative diseases. sRAGE is a soluble variant that has been proposed as an inhibitor of RAGE ...