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Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Soto-Alarcon, Sandra; Muñoz, Patricio; Corbari, Alicia; Videla, Luis A. (2018)Pharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism ...
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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
Soto-Alarcon, Sandra; Ortiz, Macarena; Orellana, Paula; Echeverría, Francisca; Bustamante, Andrés; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañán, Daniel; Valenzuela, Rodrigo; Videla, Luis A. (2019)Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ...
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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañan, Daniel; Videla, Luis A. (2019)High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the ...
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Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2
Echeverría, Francisca; Valenzuela, Rodrigo; Espinosa, Alejandra; Bustamante, Andrés; Álvarez, Daniela; Gonzalez-Mañan, Daniel; Ortiz, Macarena; Soto-Alarcon, Sandra; Videla, Luis A. (2019)High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic ...