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HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
(2019)
Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...
Pattern recognition receptors and their roles in the host response to helicobacter pylori infection
(2021)
Helicobacter pylori (H. pylori) infection is highly prevalent, affecting 4.4 billion people globally. This pathogen is a risk factor in the pathogenesis of more than 75% of worldwide cases of gastric cancer. Pattern ...
RID: evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
(2020)
Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
Polyphenols and AGEs/RAGE axis. Trends and challenges
(2020)
The formation of advanced glycation end-products (AGEs) is a key pathophysiological event linked not only to the onset and progression of diabetic complications, but also to neurodegeneration, cardiovascular diseases, ...