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Is ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary result

dc.contributor.authorRe, Lamberto
dc.contributor.authorMartínez-Sánchez, Gregorio
dc.contributor.authorBordicchia, Marica
dc.contributor.authorMalcangi, Giuseppe
dc.contributor.authorPocognoli, Antonella
dc.contributor.authorMorales-Segura, Miguel Ángel
dc.contributor.authorRothchild, John
dc.contributor.authorRojas, Armando
dc.date.accessioned2017-11-10T19:06:32Z
dc.date.available2017-11-10T19:06:32Z
dc.date.issued2014
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/1174
dc.description.abstractThe present preliminary study has been focused on verifying whether ozone preconditioning may be linked to Nrf2/EpRE (nuclear factor erythroid 2/electrophile-responsive element) activation pathway in vivo. Healthy volunteers received a total of three Major Auto-Hemotherapy (MAH) treatments, with treatments administered every second day. The amount of blood used for each subject was standardized to the value obtained multiplying the subject's body weight by 1.3 in order to ensure the same ozone concentrations for each subject. A parallel group (n¼50) age and gender matched was used as reference for the experimental variables related to the oxidative stress parameters. Levels of Nrf2 and oxidative stress index were measured throughout the study. Levels of Nrf2 (Po0.01) in peripheral blood mononuclear cells (PBMC) were found to increase immediately after ozone/oxygen exposure (35 mg/ml, prior to reinfusion). This effect was still detected (Po0.05) in total circulating PBMC when measured 30 min following reinfusion. After a series of 3 MAH, Nrf2 returned back to the basal level. At the end of the experiment the activities of superoxide dismutase and catalase were increased (Po0.05). These data demonstrate for the first time in vivo the activation of the Nrf2 pathway by a low dose of ozone and the promotion of the feedback mechanism that induces the synthesis of proteins which collectively favors cell survival.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceEuropean Journal of Pharmacology, 742, 158-162es_CL
dc.subjectOzone therapyes_CL
dc.subjectNrf2es_CL
dc.subjectNuclear factor erythroid 2es_CL
dc.subjectAutohemotherapyes_CL
dc.subjectEpREes_CL
dc.subjectElectrophile-responsive elementes_CL
dc.titleIs ozone pre-conditioning effect linked to Nrf2/EpRE activation pathway in vivo? A preliminary resultes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisibib2.ucm.cl:2048/login?url=https://www.sciencedirect.com/science/article/pii/S0014299914006347?via%3Dihub
dc.ucm.doidoi.org/10.1016/j.ejphar.2014.08.029es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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