Peroxisome proliferator-cctivated receptor targets for the treatment of metabolic diseases

Monsalve-Abaca, Francisco; Pyarasani, Radha D.; Delgado-López, Fernando; Moore-Carrasco, Rodrigo

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dc.contributor.author	Monsalve-Abaca, Francisco
dc.contributor.author	Pyarasani, Radha D.
dc.contributor.author	Delgado-López, Fernando
dc.contributor.author	Moore-Carrasco, Rodrigo
dc.date.accessioned	2017-11-15T14:05:46Z
dc.date.available	2017-11-15T14:05:46Z
dc.date.issued	2013
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/1250
dc.description.abstract	Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is growing in the adult and pediatric populations. The most widely recognized metabolic risk factors are atherogenic dyslipidemia, elevated blood pressure, and elevated plasma glucose. Individuals with these characteristics commonly manifest a prothrombotic state and a proinflammatory state as well. Peroxisome proliferator-activated receptors (PPARs) may serve as potential therapeutic targets for treating the metabolic syndrome and its related risk factors. The PPARs are transcriptional factors belonging to the ligand-activated nuclear receptor superfamily. So far, three isoforms of PPARs have been identified, namely, PPAR-𝛼, PPAR-𝛽/𝛿, and PPAR-𝛾. Various endogenous and exogenous ligands of PPARs have been identified. PPAR-𝛼 and PPAR-𝛾 are mainly involved in regulating lipid metabolism, insulin sensitivity, and glucose homeostasis, and their agonists are used in the treatment of hyperlipidemia and T2DM. Whereas PPAR-𝛽/𝛿 function is to regulate lipid metabolism, glucose homeostasis, anti-inflammation, and fatty acid oxidation and its agonists are used in the treatment of metabolic syndrome and cardiovascular diseases. This review mainly focuses on the biological role of PPARs in gene regulation and metabolic diseases, with particular focus on the therapeutic potential of PPAR modulators in the treatment of thrombosis.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	Mediators of Inflammation, 2013, 549627	es_CL
dc.title	Peroxisome proliferator-cctivated receptor targets for the treatment of metabolic diseases	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Medicina	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.doi	dx.doi.org/10.1155/2013/549627	es_CL