The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
Resumen
Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with inflammation such as in diabetes, cancer, autoimmune diseases and neurodegenerative diseases. This receptor in addition to its binding capacity for advanced glycation end-products also recognizes some molecules classified as both, pathogen- and damage-associated molecular patterns and thus triggering the transcription of genes encoding inflammatory mediators. Some of these ligands are common for both, the receptor of advanced glycation end-products and members of the Toll-like receptor family, generating shared signaling cascades. Furthermore, these receptors may cooperate as essential partners through the recruitment
and assembly of homo- and hetero-oligomers in order to strengthen the inflammatory response. The purpose of this review is to highlight the importance of some particular features of this multiligand receptor, its signaling cascade as well as the cross-talk with some members of the Toll-like receptor family.
Fuente
Cellular Signalling, 25(3), 609-614Link de Acceso
Click aquí para ver el documentoIdentificador DOI
doi.org/10.1016/j.cellsig.2012.11.022Colecciones
La publicación tiene asociados los siguientes ficheros de licencia:
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile
Publicaciones relacionadas
Mostrando publicaciones relacionadas por Título, autor o materia.
-
The emerging role of the receptor for advanced glycation end products on innate immunity
Rojas, Armando
; ; ; ; ; (2014)
Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...
-
SARS-CoV-2-mediated inflammatory response in lungs: should we look at rage?
Rojas, Armando; ; (2020)
The novel coronavirus disease (COVID-19) pandemic is placing significant strains on health systems, scientific communities, essential public services, and economies all over the world. In this context, the world´s scientific ...
-
Receptor for advanced glycation end-products axis and coronavirus disease 2019 in inflammatory bowel diseases: A dangerous liaison?
Rojas, Armando; ; ; ; (2021)
Compelling evidence supports the crucial role of the receptor for advanced glycation end-products (RAGE) axis activation in many clinical entities. Since the beginning of the coronavirus disease 2019 pandemic, there is an ...