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Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer

dc.contributor.authorRojas, Armando
dc.contributor.authorAñazco-Oyarzún, Carolina
dc.contributor.authorGonzález-Bonet, Ileana
dc.contributor.authorAraya, Paulina
dc.date.accessioned2018-05-14T20:19:23Z
dc.date.available2018-05-14T20:19:23Z
dc.date.issued2018
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/1726
dc.description.abstractA growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. Cancer cells are surrounded by a complex milieu, also known as tumor microenvironment, which contributes to the development and metastasis of tumors. Of note, one of the major components of this niche is the extracellular matrix (ECM), which becomes highly disorganized during neoplastic progression, thereby stimulating cancer cell transformation, growth and spread. One of the consequences of chronic hyperglycemia, the most frequently observed sign of diabetes and the etiological source of diabetes complications, is the irreversible glycation and oxidation of proteins and lipids leading to the formation of the advanced glycation end-products (AGEs). These compounds may covalently crosslink and biochemically modify structure and functions of many proteins, and AGEs accumulation is particularly high in long-living proteins with low biological turnover, features that are shared by most, if not all, ECM proteins. AGEs-modified proteins are recognized by AGE-binding proteins, and thus glycated ECM components have the potential to trigger Receptor for advanced glycation end-products-dependent mechanisms. The biological consequence of receptor for advanced glycation end-products activation mechanisms seems to be connected, in different ways, to drive some hallmarks of cancer onset and tumor growth. The present review intends to highlight the potential impact of ECM glycation on tumor progression by triggering receptor for advanced glycation end-products-mediated mechanisms.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceCarcinogenesis, 39(4), 515–521es_CL
dc.subjectDiabetes mellituses_CL
dc.subjectExtracellular matrixes_CL
dc.subjectCanceres_CL
dc.subjectNeoplasmses_CL
dc.subjectNeoplasms metastasises_CL
dc.subjectRAGEes_CL
dc.subjectReceptor for advanced glycation end productses_CL
dc.subjectTumor progressiones_CL
dc.subjectGlycationes_CL
dc.subjectTumor celles_CL
dc.subjectTumor microenvironmentes_CL
dc.titleExtracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and canceres_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisibib2.ucm.cl:2048/login?url=https://academic.oup.com/carcin/article/39/4/515/4823790es_CL
dc.ucm.doidoi.org/10.1093/carcin/bgy012es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile