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dc.contributor.authorBen Othman, Souad
dc.contributor.authorGhawar, Wissem
dc.contributor.authorChaouch, Melek
dc.contributor.authorAyari, Chiraz
dc.contributor.authorChemkhi, Jomaa
dc.contributor.authorCancino-Faure, Beatriz
dc.contributor.authorTomás-Pérez, Miriam
dc.contributor.authorAlcover, María Magdalena
dc.contributor.authorRiera, Cristina
dc.contributor.authorBen Salah, Afif
dc.contributor.authorFisa, Roser
dc.contributor.authorBen Ismail, Riadh
dc.contributor.authorBen Abderrazak, Souha
dc.date.accessioned2018-06-11T19:14:26Z
dc.date.available2018-06-11T19:14:26Z
dc.date.issued2018
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/1822
dc.description.abstractLeishmaniasis, a public health problem in Tunisia, are diseases caused by different Leishmania species. Cutaneous leishmaniasis is present from the North to the South under different forms, due to Leishmania (L.) major, L. infantum or L. tropica. Whereas, Psammomys (P.) obesus is the confirmed reservoir host of L. major, those of L. tropica and dermotropic L. infantum wait to be identified. Importantly, P. vexillaris species have been recently highlighted; however, no studies have been carried out to explore its potential role in leishmaniasis epidemiology. Seventy two rodents were collected from Central and South-West of Tunisia between 2007 and 2010. Using several methods, 43 animals were identified as P. obesus and 29 as P. vexillaris. Leishmania kinetoplast DNA was detected in liver samples by real-time PCR in 18 P. obesus and in 8 P. vexillaris. Then, the direct sequencing of the amplified internal transcribed spacer 1, allowed the identification of L. infantum DNA in five P. obesus and in three P. vexillaris, as well as L. tropica DNA in three other P. vexillaris. Whereas, PCR fluorescent fragment length analysis of the 7 spliced leaders, allowed identifying L. major among infected P. obesus and P. vexillaris, and interestingly co-infection (L. major/L. infantum) among two P. obesus. We report here for the first time, the infection of P. obesus, from Central Tunisia, by L. infantum. Suggesting that P. obesus the known reservoir host of L. major, may also serve as reservoir host for L. infantum and thus play a role in the spread of sporadic cutaneous or visceral leishmaniasis in this region. Of equal importance, this work establish for the first time, the natural infection of P. vexillaris by different Leishmania species, suggesting its potential epidemiological role as reservoir host.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceInfection, Genetics and Evolution, 59, 7-15es_CL
dc.subjectPsammomys obesuses_CL
dc.subjectPsammomys vexillarises_CL
dc.subjectCutaneous leishmaniasises_CL
dc.subjectMolecular studieses_CL
dc.subjectReservoir hostes_CL
dc.subjectTunisiaes_CL
dc.titleFirst detection of Leishmania DNA in Psammomys obesus and Psammomys vexillaris: Their potential involvement in the epidemiology of leishmaniasis in Tunisiaes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisibib2.ucm.cl:2048/login?url=https://www.sciencedirect.com/science/article/pii/S1567134818300133?via%3Dihubes_CL
dc.ucm.doidoi.org/10.1016/j.meegid.2018.01.013es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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