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Sustained release of linezolid from prepared hydrogels with polyvinyl alcohol and aliphatic dicarboxylic acids of variable chain lengths

dc.contributor.authorCarreño, Gustavo
dc.contributor.authorMarican, Adolfo
dc.contributor.authorVijayakumar, Sekar
dc.contributor.authorValdés-Lizama, Oscar
dc.contributor.authorCabrera-Barjas, Gustavo
dc.contributor.authorCastaño, Johanna
dc.contributor.authorDurán-Lara, Esteban F.
dc.date.accessioned2020-12-11T19:30:49Z
dc.date.available2020-12-11T19:30:49Z
dc.date.issued2020
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3356
dc.description.abstractA series of hydrogels with a specific release profile of linezolid was successfully synthesized. The hydrogels were synthesized by cross-linking polyvinyl alcohol (PVA) and aliphatic dicarboxylic acids, which include succinic acid (SA), glutaric acid (GA), and adipic acid (AA). The three crosslinked hydrogels were prepared by esterification and characterized by equilibrium swelling ratio, infrared spectroscopy, thermogravimetric analysis, mechanical properties, and scanning electron microscopy. The release kinetics studies of the linezolid from prepared hydrogels were investigated by cumulative drug release and quantified by chromatographic techniques. Mathematical models were carried out to understand the behavior of the linezolid release. These data revealed that the sustained release of linezolid depends on the aliphatic dicarboxylic acid chain length, their polarity, as well as the hydrogel crosslinking degree and mechanical properties. The in vitro antibacterial assay of hydrogel formulations was assessed in an Enterococcus faecium bacterial strain, showing a significant activity over time. The antibacterial results were consistent with cumulative release assays. Thus, these results demonstrated that the aliphatic dicarboxylic acids used as crosslinkers in the PVA hydrogels were a determining factor in the antibiotic release profile.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourcePharmaceutics, 12(10), 982es_CL
dc.subjectHydrogeles_CL
dc.subjectPolyvinyl alcoholes_CL
dc.subjectAliphatic dicarboxylic acidses_CL
dc.subjectSustained releasees_CL
dc.subjectLinezolides_CL
dc.subjectEquilibrium swelling ratioes_CL
dc.subjectAccumulative releasees_CL
dc.subjectThermogravimetric analysises_CL
dc.titleSustained release of linezolid from prepared hydrogels with polyvinyl alcohol and aliphatic dicarboxylic acids of variable chain lengthses_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.doidoi.org/10.3390/pharmaceutics12100982es_CL


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