Loss of social/non-social context discrimination by movement acceleration in the valproate model of autism

Quezada, Nelva; Salas-Ortiz, Sebastián; Peralta, Francisco; Aguayo, Felipe; Morgado-Gallardo, Katherine; Mac-Rae, Catherine A.; Fiedler, Jenny L.; Aliaga-Rojas, Esteban

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dc.contributor.author	Quezada, Nelva
dc.contributor.author	Salas-Ortiz, Sebastián
dc.contributor.author	Peralta, Francisco
dc.contributor.author	Aguayo, Felipe
dc.contributor.author	Morgado-Gallardo, Katherine
dc.contributor.author	Mac-Rae, Catherine A.
dc.contributor.author	Fiedler, Jenny L.
dc.contributor.author	Aliaga-Rojas, Esteban
dc.date.accessioned	2021-12-09T19:46:50Z
dc.date.available	2021-12-09T19:46:50Z
dc.date.issued	2021
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/3557
dc.description.abstract	Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information about whether movement alterations in ASD comprise modifications at the basic kinematic level, such as trajectory and velocity, which may contribute to the higher level of processing that allows the perception and interpretation of actions performed by others, and hence, impact social interaction. In order to further explore possible motor alterations in ASD, we analyzed movement parameters in the Valproate (VPA) animal model of autism. We found that VPA-treated rats displayed greater movement acceleration, reduced distance between stops, spent more time in the corner of the open-field arena, and executed a number of particular behaviors; for example, supported rearing and circling, with no major changes in distance and velocity. However, in the social interaction test, we found other alterations in the movement parameters. In addition to increased acceleration, VPA-rats displayed reduced velocity, increased stops, reduced distance/stop and lost the social/non-social area discrimination that is characteristic of control rats in acceleration and stops variables. Hence, even if prenatal VPA-treatment could have a minor effect in motor variables in a non-social context, it has a crucial effect in the capacity of the animals to adjust their kinematic variables when social/non-social context alternation is required.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	Frontiers in Behavioral Neuroscience, 14, 555610	es_CL
dc.title	Loss of social/non-social context discrimination by movement acceleration in the valproate model of autism	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Ciencias de la Salud	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	www.frontiersin.org/articles/10.3389/fnbeh.2020.555610/full	es_CL
dc.ucm.doi	doi.org/10.3389/fnbeh.2020.555610	es_CL