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Global monitoring of antimicrobial resistance based on metagenomics analyses of urban sewage

dc.contributor.authorHendriksen, Rene S.
dc.contributor.authorMunk, Patrick
dc.contributor.authorNjage, Patrick
dc.contributor.authorBunnik, Bram van
dc.contributor.authorMcNally, Luke
dc.contributor.authorLukjancenko, Oksana
dc.contributor.authorRöder, Timo
dc.contributor.authorNieuwenhuijse, David
dc.contributor.authorKarlsmose Pedersen, Susanne
dc.contributor.authorKjeldgaard, Jette S.
dc.contributor.authorKaas, Rolf S.
dc.contributor.authorClausen, Philip T. L. C.
dc.contributor.authorVogt, Josef K.
dc.contributor.authorLeekitcharoenphon, Pimlapas
dc.contributor.authorvan de Schans, Milou G.M.
dc.contributor.authorZuidema, Tina
dc.contributor.authorde Roda Husman, Ana M.
dc.contributor.authorRasmussen, Simon
dc.contributor.authorPetersen, Bent
dc.contributor.authorAmid, Clara
dc.contributor.authorCochrane, Guy
dc.contributor.authorSicheritz-Ponten, Thomas
dc.contributor.authorSchmitt, Heike
dc.contributor.authorMatheu Alvarez, Jorge R.
dc.contributor.authorAidara-Kane, Awa
dc.contributor.authorPamp, Sünje J.
dc.contributor.authorLund, Ole
dc.contributor.authorHald, Tine
dc.contributor.authorWoolhouse, Mark
dc.contributor.authorKoopmans, Marion
dc.contributor.authorVigre, Håkan
dc.contributor.authorPetersen, Thomas N.
dc.contributor.authorAarestrup, Frank M.
dc.date.accessioned2023-03-22T17:42:15Z
dc.date.available2023-03-22T17:42:15Z
dc.date.issued2019
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4554
dc.description.abstractAntimicrobial resistance (AMR) is a serious threat to global public health, but obtaining representative data on AMR for healthy human populations is difficult. Here, we use metagenomic analysis of untreated sewage to characterize the bacterial resistome from 79 sites in 60 countries. We find systematic differences in abundance and diversity of AMR genes between Europe/North-America/Oceania and Africa/Asia/South-America. Antimicrobial use data and bacterial taxonomy only explains a minor part of the AMR variation that we observe. We find no evidence for cross-selection between antimicrobial classes, or for effect of air travel between sites. However, AMR gene abundance strongly correlates with socio-economic, health and environmental factors, which we use to predict AMR gene abundances in all countries in the world. Our findings suggest that global AMR gene diversity and abundance vary by region, and that improving sanitation and health could potentially limit the global burden of AMR. We propose metagenomic analysis of sewage as an ethically acceptable and economically feasible approach for continuous global surveillance and prediction of AMR.es_CL
dc.description.sponsorshipThe Global Sewage Surveillance Project Consortiumes_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceNature Communications, 10, 1124es_CL
dc.subjectAntimicrobial resistancees_CL
dc.subjectEcological epidemiologyes_CL
dc.subjectMetagenomicses_CL
dc.subjectWater microbiologyes_CL
dc.titleGlobal monitoring of antimicrobial resistance based on metagenomics analyses of urban sewagees_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias Agrarias y Forestaleses_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urisibib2.ucm.cl:2048/login?url=https://www.nature.com/articles/s41467-019-08853-3es_CL
dc.ucm.doidoi.org/10.1038/s41467-019-08853-3es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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