Lysyl oxidase isoforms in gastric cancer
Autor
Delgado-López, Fernando
Araya, Paulina
González-Bonet, Ileana
Morales-Mejías, Erik
Pérez-Castro, Ramón
Romero, Jacqueline
Añazco-Oyarzún, Carolina
Fecha
2016Resumen
Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular matrix crosslinking enzymes, should be considered as potential biomarkers and therapeutic targets in GC. In this review, we focus on the expression levels of lysyl oxidase isoforms, its functions and the clinical implications in GC. Finding novel proteins related to the processing of these extracellular matrix enzymes might be helpful in the design of new therapies, which, in combination with classic pharmacology, could be used to delay the progress of this aggressive cancer and offer a wider temporal window for clinical intervention.
Fuente
Biomarkers in Medicine, 10(9), 987-998Link de Acceso
Click aquí para ver el documentoIdentificador DOI
doi.org/10.2217/bmm-2016-0075Colecciones
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