Dose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study

Boonpor, Jirapitcha; Parra‑Soto, Solange; Petermann-Rocha, Fanny; Lynskey, Nathan; Cabanas-Sánchez, Verónica; Sattar, Naveed; Gill, Jason M.R.; Welsh, Paul; Pell, J.P.; Gray, S.R.; Ho, Frederick; Celis-Morales, Carlos

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dc.contributor.author	Boonpor, Jirapitcha
dc.contributor.author	Parra‑Soto, Solange
dc.contributor.author	Petermann-Rocha, Fanny
dc.contributor.author	Lynskey, Nathan
dc.contributor.author	Cabanas-Sánchez, Verónica
dc.contributor.author	Sattar, Naveed
dc.contributor.author	Gill, Jason M.R.
dc.contributor.author	Welsh, Paul
dc.contributor.author	Pell, J.P.
dc.contributor.author	Gray, S.R.
dc.contributor.author	Ho, Frederick
dc.contributor.author	Celis-Morales, Carlos
dc.date.accessioned	2023-06-14T15:10:25Z
dc.date.available	2023-06-14T15:10:25Z
dc.date.issued	2023
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/4849
dc.description.abstract	Background Most studies investigating the association between physical activity (PA) and the risk of type 2 diabetes are derived from self-reported questionnaires, with limited evidence using device-based measurements. Therefore, this study aimed to investigate the dose–response relationship between device-measured PA and incident type 2 diabetes. Methods This prospective cohort study included 40,431 participants of the UK Biobank. Wrist-worn accelerometers were used to estimate total, light, moderate, vigorous and moderate-to-vigorous PA. The associations between PA and incident type 2 diabetes were analysed using Cox-proportional hazard models. The mediating role of body mass index (BMI) was tested under a causal counterfactual framework. Results The median follow-up period was 6.3 years (IQR: 5.7–6.8), with 591 participants developing type 2 diabetes. Compared to those achieving < 150 min/week of moderate PA, people achieving 150–300, 300–600 and > 600 min/week were at 49% (95% CI 62–32%), 62% (95% CI 71–50%) and 71% (95% CI 80–59%) lower risk of type 2 diabetes, respectively. For vigorous PA, compared to those achieving < 25 min/week, individuals achieving 25–50, 50–75 and > 75 min/week were at 38% (95% CI 48–33%), 48% (95% CI 64–23%) and 64% (95% CI 78–42%) lower type 2 diabetes risk, respectively. Twelve per cent and 20% of the associations between vigorous and moderate PA and type 2 diabetes were mediated by lower BMI, respectively. Conclusions PA has clear dose-response relationship with a lower risk of type 2 diabetes. Our findings support the current aerobic PA recommendations but suggest that additional PA beyond the recommendations is associated with even greater risk reduction. Trial registration The UK Biobank study was approved by the North West Multi-Centre Research Ethics Committee (Ref 11/NW/0382 on June 17, 2011).	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	BMC Medicine, 21(1), 191	es_CL
dc.subject	Accelerometer	es_CL
dc.subject	Obesity	es_CL
dc.subject	Physical activity	es_CL
dc.subject	Type 2 diabetes mellitus	es_CL
dc.title	Dose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study	es_CL
dc.type	Article	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-02851-5	es_CL