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Neurophysiological markers of premotor–motor network plasticity predict motor performance in young and older adults

dc.contributor.authorTurrini, Sonia
dc.contributor.authorBevacqua, Naomi
dc.contributor.authorCataneo, Antonio
dc.contributor.authorChiappini, Emilio
dc.contributor.authorFiori, Francesca
dc.contributor.authorBattaglia, Simone
dc.contributor.authorRomei, Vincenzo
dc.contributor.authorAvenanti, Alessio
dc.date.accessioned2023-07-10T19:53:21Z
dc.date.available2023-07-10T19:53:21Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4861
dc.description.abstractAging is commonly associated with a decline in motor control and neural plasticity. Tuning cortico–cortical interactions between premotor and motor areas is essential for controlling fine manual movements. However, whether plasticity in premotor–motor circuits predicts hand motor abilities in young and elderly humans remains unclear. Here, we administered transcranial magnetic stimulation (TMS) over the ventral premotor cortex (PMv) and primary motor cortex (M1) using the cortico–cortical paired-associative stimulation (ccPAS) protocol to manipulate the strength of PMv-to-M1 connectivity in 14 young and 14 elderly healthy adults. We assessed changes in motor-evoked potentials (MEPs) during ccPAS as an index of PMv-M1 network plasticity. We tested whether the magnitude of MEP changes might predict interindividual differences in performance in two motor tasks that rely on premotor-motor circuits, i.e., the nine-hole pegboard test and a choice reaction task. Results show lower motor performance and decreased PMv-M1 network plasticity in elderly adults. Critically, the slope of MEP changes during ccPAS accurately predicted performance at the two tasks across age groups, with larger slopes (i.e., MEP increase) predicting better motor performance at baseline in both young and elderly participants. These findings suggest that physiological indices of PMv-M1 plasticity could provide a neurophysiological marker of fine motor control across age-groups.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBiomedicines, 11(5), 1464es_CL
dc.subjectAginges_CL
dc.subjectConnectivityes_CL
dc.subjectPlasticityes_CL
dc.subjectPremotor cortexes_CL
dc.subjectMotor cortexes_CL
dc.subjectMotor performancees_CL
dc.subjectTranscranial magnetic stimulationes_CL
dc.titleNeurophysiological markers of premotor–motor network plasticity predict motor performance in young and older adultses_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.urimdpi.com/2227-9059/11/5/1464es_CL
dc.ucm.doidoi.org/10.3390/biomedicines11051464es_CL


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