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The role of Serotonin in fear learning and memory: a systematic review of human studies

dc.contributor.authorTortora, Francesco
dc.contributor.authorHadipour, Abed L.
dc.contributor.authorBattaglia, Simone
dc.contributor.authorFalzone, Alessandra
dc.contributor.authorAvenanti, Alessio
dc.contributor.authorVicario, C.M.
dc.date.accessioned2023-09-26T15:03:32Z
dc.date.available2023-09-26T15:03:32Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/4983
dc.description.abstractFear is characterized by distinct behavioral and physiological responses that are essential for the survival of the human species. Fear conditioning (FC) serves as a valuable model for studying the acquisition, extinction, and expression of fear. The serotonin (5-hydroxytryptamine, 5-HT) system is known to play a significant role in emotional and motivational aspects of human behavior, including fear learning and expression. Accumulating evidence from both animal and human studies suggests that brain regions involved in FC, such as the amygdala, hippocampus, and prefrontal cortex, possess a high density of 5-HT receptors, implicating the crucial involvement of serotonin in aversive learning. Additionally, studies exploring serotonin gene polymorphisms have indicated their potential influence on FC. Therefore, the objective of this work was to review the existing evidence linking 5-HT with fear learning and memory in humans. Through a comprehensive screening of the PubMed and Web of Science databases, 29 relevant studies were included in the final review. These studies investigated the relationship between serotonin and fear learning using drug manipulations or by studying 5-HT-related gene polymorphisms. The results suggest that elevated levels of 5-HT enhance aversive learning, indicating that the modulation of serotonin 5-HT2A receptors regulates the expression of fear responses in humans. Understanding the role of this neurochemical messenger in associative aversive learning can provide insights into psychiatric disorders such as anxiety and post-traumatic stress disorder (PTSD), among others.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBrain Sciences, 13(8), 1197es_CL
dc.subjectHuman fear conditioninges_CL
dc.subjectFear memoryes_CL
dc.subjectSerotonines_CL
dc.subject5-HT receptores_CL
dc.subjectSelective serotonin reuptake inhibitors (SSRIs)es_CL
dc.subjectAcute tryptophan depletion (ATD)es_CL
dc.subject5-HTT polymorphismses_CL
dc.titleThe role of Serotonin in fear learning and memory: a systematic review of human studieses_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/2076-3425/13/8/1197es_CL
dc.ucm.doidoi.org/10.3390/brainsci13081197es_CL


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