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Changes in preterm birth and stillbirth during COVID-19 lockdowns in 26 countries

dc.contributor.authorCalvert, Clara
dc.contributor.authorBrockway, Meredith
dc.contributor.authorZoega, Helga
dc.contributor.authorMiller, Jessica E.
dc.contributor.authorBeen, Jasper V.
dc.contributor.authorKofi Amegah, Adeladza
dc.contributor.authorRacine-Poon, Amy
dc.contributor.authorEradat Oskoui, Solmaz
dc.contributor.authorAbok, Ishaya I.
dc.contributor.authorAghaeepour, Nima
dc.contributor.authorAkwaowo, Christie D.
dc.contributor.authorAlshaikh, Belal N.
dc.contributor.authorAyede, Adejumoke I.
dc.contributor.authorBacchini, Fabiana
dc.contributor.authorBarekatain, Behzad
dc.contributor.authorBarnes, Rodrigo
dc.contributor.authorBebak, Karolina
dc.contributor.authorBerard, Anick
dc.contributor.authorBhutta, Zulfiqar A.
dc.contributor.authorBrook, Jeffrey R.
dc.contributor.authorBryan, Lenroy R.
dc.contributor.authorCajachagua-Torres, Kim N.
dc.contributor.authorCampbell-Yeo, Marsha
dc.contributor.authorDinh-Toi, Chu
dc.contributor.authorAzad, Meghan B.
dc.date.accessioned2023-11-30T17:27:50Z
dc.date.available2023-11-30T17:27:50Z
dc.date.issued2023
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5106
dc.description.abstractPreterm birth (PTB) is the leading cause of infant mortality worldwide. Changes in PTB rates, ranging from −90% to +30%, were reported in many countries following early COVID-19 pandemic response measures (‘lockdowns’). It is unclear whether this variation reflects real differences in lockdown impacts, or perhaps differences in stillbirth rates and/or study designs. Here we present interrupted time series and meta-analyses using harmonized data from 52 million births in 26 countries, 18 of which had representative population-based data, with overall PTB rates ranging from 6% to 12% and stillbirth ranging from 2.5 to 10.5 per 1,000 births. We show small reductions in PTB in the first (odds ratio 0.96, 95% confidence interval 0.95–0.98, P value <0.0001), second (0.96, 0.92–0.99, 0.03) and third (0.97, 0.94–1.00, 0.09) months of lockdown, but not in the fourth month of lockdown (0.99, 0.96–1.01, 0.34), although there were some between-country differences after the first month. For high-income countries in this study, we did not observe an association between lockdown and stillbirths in the second (1.00, 0.88–1.14, 0.98), third (0.99, 0.88–1.12, 0.89) and fourth (1.01, 0.87–1.18, 0.86) months of lockdown, although we have imprecise estimates due to stillbirths being a relatively rare event. We did, however, find evidence of increased risk of stillbirth in the first month of lockdown in high-income countries (1.14, 1.02–1.29, 0.02) and, in Brazil, we found evidence for an association between lockdown and stillbirth in the second (1.09, 1.03–1.15, 0.002), third (1.10, 1.03–1.17, 0.003) and fourth (1.12, 1.05–1.19, <0.001) months of lockdown. With an estimated 14.8 million PTB annually worldwide, the modest reductions observed during early pandemic lockdowns translate into large numbers of PTB averted globally and warrant further research into causal pathways.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceNature Human Behaviour, 7, 529-544es_CL
dc.titleChanges in preterm birth and stillbirth during COVID-19 lockdowns in 26 countrieses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias de la Saludes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urinature.com/articles/s41562-023-01522-y#Sec2es_CL
dc.ucm.doidoi.org/10.1038/s41562-023-01522-yes_CL


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