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Large conductance voltage-and calcium-activated K+ (BK) channel in health and disease

dc.contributor.authorEcheverría, Felipe
dc.contributor.authorGonzalez-Sanabria, Naileth
dc.contributor.authorAlvarado-Sanchez, Rosangelina
dc.contributor.authorFernández, Miguel
dc.contributor.authorCastillo, Karen
dc.contributor.authorLatorre, Ramón
dc.date.accessioned2024-04-30T18:39:19Z
dc.date.available2024-04-30T18:39:19Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5361
dc.description.abstractLarge Conductance Voltage- and Calcium-activated K+ (BK) channels are transmembrane pore-forming proteins that regulate cell excitability and are also expressed in non-excitable cells. They play a role in regulating vascular tone, neuronal excitability, neurotransmitter release, and muscle contraction. Dysfunction of the BK channel can lead to arterial hypertension, hearing disorders, epilepsy, and ataxia. Here, we provide an overview of BK channel functioning and the implications of its abnormal functioning in various diseases. Understanding the function of BK channels is crucial for comprehending the mechanisms involved in regulating vital physiological processes, both in normal and pathological conditions, controlled by BK. This understanding may lead to the development of therapeutic interventions to address BK channelopathies.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceFrontiers in Pharmacology, 15, 1373507es_CL
dc.subjectBK channeles_CL
dc.subjectKCNMA1es_CL
dc.subjectChannelopathieses_CL
dc.subjectPhysiologyes_CL
dc.subjectMolecular and cellular mechanismses_CL
dc.subjectCellular excitabilityes_CL
dc.titleLarge conductance voltage-and calcium-activated K+ (BK) channel in health and diseasees_CL
dc.typeArticlees_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urifrontiersin.org/journals/pharmacology/articles/10.3389/fphar.2024.1373507/full#h1es_CL
dc.ucm.doidoi.org/10.3389/fphar.2024.1373507es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile