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11-Deoxycorticosterone (DOC)’s action on the gill osmoregulation of juvenile rainbow trout (Oncorhynchus mykiss)

dc.contributor.authorZuloaga, Rodrigo
dc.contributor.authorAhumada-Langer, Luciano
dc.contributor.authorAedo, Jorge Eduardo
dc.contributor.authorMolina, Alfredo
dc.contributor.authorValdés, Juan Antonio
dc.date.accessioned2024-05-07T15:55:18Z
dc.date.available2024-05-07T15:55:18Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5371
dc.description.abstractIn aquaculture, stress can negatively affect fish growth. For years, the cortisol hormone has been thought to play both glucocorticoid and mineralocorticoid functions. Nevertheless, recent research has suggested that 11-deoxycorticosterone (DOC) released during stress could contribute to cortisol actions, though this process is still misunderstood. Here, we evaluated the DOC effects on physiological and early transcriptional responses by RNA-seq. Juvenile rainbow trout were treated with DOC and/or glucocorticoids (mifepristone) or mineralocorticoid (eplerenone) receptor antagonists. Subsequently, plasma was collected, and cDNA libraries were generated from the gills of vehicle (control), DOC, mifepristone, mifepristone with DOC, eplerenone, and eplerenone with DOC groups. Calcium and phosphate levels in plasma were changed. Results revealed 914 differentially expressed transcripts (DETs) induced by DOC compared with control, mainly associated with sodium ion transmembrane transport, gluconeogenesis, negative regulation of transmembrane transport, and activation of innate immune response. DOC versus eplerenone with DOC comparison displayed 444 DETs related to cell-cell junction organization, canonical glycolysis, positive regulation of immune response, and potassium ion transport. Conversely, no DETs were detected in DOC versus mifepristone with DOC comparison. These data suggest that DOC has a relevant role in gill stress response and ion transport, which is differentially regulated by mineralocorticoid receptors.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBiology, 13(2), 107es_CL
dc.subjectDOCes_CL
dc.subjectMineralocorticoid receptores_CL
dc.subjectStress responsees_CL
dc.subjectRNA-seqes_CL
dc.subjectGillses_CL
dc.subjectSalmonides_CL
dc.title11-Deoxycorticosterone (DOC)’s action on the gill osmoregulation of juvenile rainbow trout (Oncorhynchus mykiss)es_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias Básicases_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/2079-7737/13/2/107es_CL
dc.ucm.doidoi.org/10.3390/biology13020107es_CL


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