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The RAGE axis: a relevant inflammatory hub in human diseases

dc.contributor.authorRojas, Armando
dc.contributor.authorLindner, Cristian
dc.contributor.authorSchneider, Ivan
dc.contributor.authorGonzalez, Ileana
dc.contributor.authorUribarri, Jaime
dc.date.accessioned2024-06-05T15:21:33Z
dc.date.available2024-06-05T15:21:33Z
dc.date.issued2024
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/5415
dc.description.abstractIn 1992, a transcendental report suggested that the receptor of advanced glycation end-products (RAGE) functions as a cell surface receptor for a wide and diverse group of compounds, commonly referred to as advanced glycation end-products (AGEs), resulting from the non-enzymatic glycation of lipids and proteins in response to hyperglycemia. The interaction of these compounds with RAGE represents an essential element in triggering the cellular response to proteins or lipids that become glycated. Although initially demonstrated for diabetes complications, a growing body of evidence clearly supports RAGE’s role in human diseases. Moreover, the recognizing capacities of this receptor have been extended to a plethora of structurally diverse ligands. As a result, it has been acknowledged as a pattern recognition receptor (PRR) and functionally categorized as the RAGE axis. The ligation to RAGE leads the initiation of a complex signaling cascade and thus triggering crucial cellular events in the pathophysiology of many human diseases. In the present review, we intend to summarize basic features of the RAGE axis biology as well as its contribution to some relevant human diseases such as metabolic diseases, neurodegenerative, cardiovascular, autoimmune, and chronic airways diseases, and cancer as a result of exposure to AGEs, as well as many other ligands.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceBiomolecules, 14(4), 412es_CL
dc.subjectAdvanced glycation end-productses_CL
dc.subjectAlarminses_CL
dc.subjectHuman diseaseses_CL
dc.subjectPathophysiologyes_CL
dc.subjectChronic inflammationes_CL
dc.titleThe RAGE axis: a relevant inflammatory hub in human diseaseses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/2218-273X/14/4/412es_CL
dc.ucm.doidoi.org/10.3390/biom14040412es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile