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Anticancer potential, phenolic profile, and antioxidant properties of Synsepalum dulcificum (miracle berry) in colorectal tumor cell lines

dc.contributor.authorQuiroz-Troncoso, Josefa
dc.contributor.authorAlegría-Aravena, Nicolás
dc.contributor.authorSáenz de Mierae, Blanca
dc.contributor.authorSánchez-Díez, Marta
dc.contributor.authorGonzález-Martos, Raquel
dc.contributor.authorGavira-O’Neill, Clara E.
dc.contributor.authorGonzález, Emilio J.
dc.contributor.authorGonzález-Miquel, Maria
dc.contributor.authorValdés Vergara, Cristian
dc.contributor.authorGonzález-Silva, Gloria
dc.contributor.authorBensadon-Naeder, Loan
dc.contributor.authorGaleano, Javier
dc.contributor.authorRamírez-Castillejo, Carmen
dc.date.accessioned2025-07-04T18:06:34Z
dc.date.available2025-07-04T18:06:34Z
dc.date.issued2025
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/6182
dc.description.abstractPolyphenols, recognized for their antioxidant capacity, have shown potential in improving the response treatment of various diseases, including cancer. In this context, polyphenols have the ability to induce cytotoxicity in tumor cells, making them possible complementary agents to current treatments. The present study aims to evaluate the effect of the aqueous extract of Synsepalum dulcificum, using the commercial product DMB®, on the proliferation of colorectal tumor cells. An aqueous extract of DMB® was obtained, and 12 compounds were identified through high-performance liquid chromatography (HPLC), with protocatechuic acid, gallic acid, and catechin being the most prominent. Regarding cytotoxicity, the extracts reduced cell viability in the DLD-1, HT29, SW480, and SW620 cell lines, with IC50 values of 7, 11, 13, and 15 mg/mL, respectively. The combination of oxaliplatin with the DMB® extract reduced the resistant population by up to 50% in the DLD-1 and SW620 cell lines, affecting the G2/M and S phases of the cell cycle, respectively. Additionally, treatment with the DMB® extract induced an increase in the expression of BCL2, CASP3, and CASP9, suggesting a mechanism of action associated with apoptosis. The aqueous extract of Synsepalum dulcificum (DMB®) exhibited cytotoxicity in colorectal cancer cells, enhancing the effect of oxaliplatin and activating apoptotic pathways, suggesting its potential as an adjuvant in anticancer therapies.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceAntioxidants, 14(4), 381es_CL
dc.subjectSynsepalum dulcificumes_CL
dc.subjectAntioxidant activityes_CL
dc.subjectAnticancer activityes_CL
dc.subjectColorectal canceres_CL
dc.subjectApoptotic pathwayses_CL
dc.subjectCell cyclees_CL
dc.titleAnticancer potential, phenolic profile, and antioxidant properties of Synsepalum dulcificum (miracle berry) in colorectal tumor cell lineses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Ciencias Agrarias y Forestaleses_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urimdpi.com/2076-3921/14/4/381es_CL
dc.ucm.doidoi.org/10.3390/antiox14040381es_CL


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