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Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats
Aliaga-Rojas, Esteban; Pacheco, Aníbal; Aguayo, Felipe I.; Muñoz, Mauricio; García-Rojo, Gonzalo; Olave, Felipe A.; Parra-Fiedler, Nicolás; García-Pérez, Alexandra; Tejos-Bravo, Macarena; Rojas, Paulina S.; Parra, Claudio S.; Fiedler, Jenny L. (2017)Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared ...
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Hippocampal memory recovery after acute stress: A behavioral, morphological and molecular study
Aguayo, Felipe I.; Tejos-Bravo, Macarena; Díaz-Véliz, Gabriela; Pacheco, Aníbal; García-Rojo, Gonzalo; Corrales, Wladimir; Olave, Felipe A.; Aliaga-Rojas, Esteban; Ulloa, José L.; Avalos, Ana M.; Román-Albasini, Luciano; Rojas, Paulina S.; Fiedler, Jenny L. (2018)Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to ...
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MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: Relevance to depression pathophysiology
Muñoz-Llanos, Mauricio; García-Pérez, María A.; Xu, Xiaojiang; Tejos-Bravo, Macarena; Vidal, Elena A.; Moyano, Tomás C.; Gutiérrez, Rodrigo A.; Aguayo, Felipe I.; Pacheco, Aníbal; García-Rojo, Gonzalo; Aliaga-Rojas, Esteban; Rojas, Paulina S.; Cidlowski, John A.; Fiedler, Jenny L. (2018)Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including ...
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The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
Aliaga-Rojas, Esteban; García-Rojo, Gonzalo; Fresno, Cristóbal; Vilches, Natalia; Mora, Sergio; Tejos, Macarena; Díaz-Véliz, Gabriela; Aguayo, Felipe I.; Fiedler, Jenny L.; Parra, Claudio S.; Parra-Fiedler, Nicolás; Rojas, Paulina S.; Pacheco, Aníbal (2017)Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...