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Alteraciones en variables cinemáticas y conductas exploratorias en prueba de campo abierto en modelo de autismo inducido por exposición prenatal al ácido valproico
Quezada, Nelva; Nuñez-Contador, Karla; Salas-Ortiz, Sebastián; Peralta, Francisco; Aguayo, Felipe; Morgado-Gallardo, Katherine; Fiedler, Jenny L.; Aliaga-Rojas, Esteban (2020)El trastorno del espectro autista (TEA), en grupo heterogéneo de desórdenes del neurodesarrollo, caracterizado por déficit social y conductas restringidas/estereotipadas, acompañado de otras comorbilidades. Este trastorno ...
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Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically stressed male rats
Román-Albasini, Luciano; Díaz-Véliz, Gabriela; Olave, Felipe A.; Aguayo, Felipe; García-Rojo, Gonzalo; Corrales, Wladimir; Silva, Juan P.; Ávalos, Ana; Rojas, Paulina S.; Aliaga-Rojas, Esteban; Fiedler, Jenny L. (2020)Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated ...
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Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats
Aliaga-Rojas, Esteban; Pacheco, Aníbal; Aguayo, Felipe I.; Muñoz, Mauricio; García-Rojo, Gonzalo; Olave, Felipe A.; Parra-Fiedler, Nicolás; García-Pérez, Alexandra; Tejos-Bravo, Macarena; Rojas, Paulina S.; Parra, Claudio S.; Fiedler, Jenny L. (2017)Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared ...
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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
Tejos-Bravo, Macarena; Oakley, Robert H.; Whirledge, Shannon D.; Corrales, Wladimir; Silva, Juan P.; García-Rojo, Gonzalo; Toledo, Jorge; Sanchez, Wendy; Román-Albasini, Luciano; Aliaga-Rojas, Esteban; Aguayo, Felipe; Olave, Felipe A.; Marcaja-Coutinho, Vinicius; Cidlowski, John A.; Fiedler, Jenny L. (2021)Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
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La discriminación contextual no social e inmunorreactividad de mTOR mantenida en el hipocampo dorsal de ratas tratadas prenatalmente con Ácido Valproico
Mac-Rae, Catherine A.; Morgado-Gallardo, Katherine; Peralta, Francisco; Fiedler, Jenny L.; Aliaga-Rojas, Esteban (2022)El espectro del trastorno autista (TDA) es un desorden del neurodesarrollo caracterizado por un profundo déficit en el lenguaje y en las interacciones sociales, acompañado por comportamientos restringidos, estereotípicos ...
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Dual effect of serotonin on the dendritic growth of cultured hippocampal neurons: Involvement of 5-HT1A and 5-HT7 receptors
Aliaga-Rojas, Esteban; Rojas, P.S.; Aguayo, Felipe I.; Neira, D.; Muñoz, J.P.; Tejos-Bravo, Macarena; Parra, Claudio S.; Fiedler, Jenny L. (2017)Serotonin acts through its receptors (5-HTRs) to shape brain networks during development and modulates essential functions in mature brain. The 5-HT1AR is mainly located at soma of hippocampal neurons early during brain ...
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Hippocampal memory recovery after acute stress: A behavioral, morphological and molecular study
Aguayo, Felipe I.; Tejos-Bravo, Macarena; Díaz-Véliz, Gabriela; Pacheco, Aníbal; García-Rojo, Gonzalo; Corrales, Wladimir; Olave, Felipe A.; Aliaga-Rojas, Esteban; Ulloa, José L.; Avalos, Ana M.; Román-Albasini, Luciano; Rojas, Paulina S.; Fiedler, Jenny L. (2018)Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to ...
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Loss of social/non-social context discrimination by movement acceleration in the valproate model of autism
Quezada, Nelva; Salas-Ortiz, Sebastián; Peralta, Francisco; Aguayo, Felipe; Morgado-Gallardo, Katherine; Mac-Rae, Catherine A.; Fiedler, Jenny L.; Aliaga-Rojas, Esteban (2021)Autism spectrum disorder (ASD) is a neurodevelopmental alteration characterized by social/communicative deficits, repetitive/stereotyped movements, and restricted/obsessive interests. However, there is not much information ...
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MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: Relevance to depression pathophysiology
Muñoz-Llanos, Mauricio; García-Pérez, María A.; Xu, Xiaojiang; Tejos-Bravo, Macarena; Vidal, Elena A.; Moyano, Tomás C.; Gutiérrez, Rodrigo A.; Aguayo, Felipe I.; Pacheco, Aníbal; García-Rojo, Gonzalo; Aliaga-Rojas, Esteban; Rojas, Paulina S.; Cidlowski, John A.; Fiedler, Jenny L. (2018)Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including ...
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Region-specific reduction of BDNF protein and transcripts in the hippocampus of juvenile rats prenatally treated with sodium valproate
Fuentealba, Constanza; Fiedler, Jenny L.; Peralta, Francisco; Avalos, Ana M.; Aguayo, Felipe I.; Morgado-Gallardo, Katherine; Aliaga-Rojas, Esteban (2019)Autism is a neurodevelopmental disorder characterized by a deep deficit in language and social interaction, accompanied by restricted, stereotyped and repetitive behaviors. The use of genetic autism animal models has ...
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Sex-dependent changes of miRNA levels in the hippocampus of adrenalectomized rats following acute corticosterone administration
Corrales, Wladimir; Silva, Juan P.; Parra, Claudio S.; Olave, Felipe A.; Aguayo, Felipe; Román-Albasini, Luciano; Aliaga-Rojas, Esteban; Venegas-Zamora, Leslye; Avalos, Ana M.; Rojas, P.S.; Marcaja-Coutinho, Vinicius; Oakley, Robert H.; Cidlowski, John A.; Fiedler, Jenny L. (2021)We explored sex-biased effects of the primary stress glucocorticoid hormone corticosterone on the miRNA expression profile in the rat hippocampus. Adult adrenalectomized (ADX) female and male rats received a single ...
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The ROCK inhibitor fasudil prevents chronic restraint stress-induced depressive-like behaviors and dendritic spine loss in rat hippocampus
Aliaga-Rojas, Esteban; García-Rojo, Gonzalo; Fresno, Cristóbal; Vilches, Natalia; Mora, Sergio; Tejos, Macarena; Díaz-Véliz, Gabriela; Aguayo, Felipe I.; Fiedler, Jenny L.; Parra, Claudio S.; Parra-Fiedler, Nicolás; Rojas, Paulina S.; Pacheco, Aníbal (2017)Background: Dendritic arbor simplification and dendritic spine loss in the hippocampus, a limbic structure implicated in mood disorders, are assumed to contribute to symptoms of depression. These morphological changes imply ...