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A peptide backbone stapling strategy enabled by the multicomponent incorporation of amide n-substituents
Ricardo, Manuel G.; Marrrero, Javiel F.; Valdés, Oscar; Rivera, Daniel G.; Wessjohann, Ludger A. (2019)The multicomponent backbone N-modification of peptides on solid-phase is presented as a powerful and general method to enable peptide stapling at the backbone instead of the side chains. This work shows that a variety of ...
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Synthesis of lactam-bridged and lipidated cyclo-peptides as promising anti-phytopathogenic agents
Vasco, Aldrin V.; Brode, Martina; Méndez, Yanira; Valdés-Lizama, Oscar; Rivera, Daniel G.; Wessjohann, Ludger A. (2020)Antimicrobial resistance to conventional antibiotics and the limited alternatives to combat plant-threatening pathogens are worldwide problems. Antibiotic lipopeptides exert remarkable membrane activity, which usually is ...