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Mostrando publicaciones 1-11 de 11
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Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Soto-Alarcon, Sandra; Muñoz, Patricio; Corbari, Alicia; Videla, Luis A. (2018)Pharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism ...
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Colloidal carbon stimulation of Kupffer cells triggers Nrf2 activation in the isolated perfused rat liver
Núñez, Bárbara; Vargas, Romina; Castillo-Montecinos, Iván; Videla, Luis A. (2012)Activation of transcription factor Nrf2 was investigated in the isolated perfused rat liver infused with 0.5 mg of colloidal carbon (CC)/ml for 5–15 min to stimulated Kupffer cell function. Infusion of CC enhanced liver ...
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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
Soto-Alarcon, Sandra; Ortiz, Macarena; Orellana, Paula; Echeverría, Francisca; Bustamante, Andrés; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañán, Daniel; Valenzuela, Rodrigo; Videla, Luis A. (2019)Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ...
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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañan, Daniel; Videla, Luis A. (2019)High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the ...
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Hydroxytyrosol and Cytoprotection: A projection for clinical interventions
Ortiz-Manrique, Macarena; Echeverría, Francisca; Valenzuela, Rodrigo; Videla, Luis A. (2017)Hydroxytyrosol (HT) ((3,4-Dihydroxyphenyl)ethanol) is a polyphenol mainly present in extra virgin olive oil (EVOO) but also in red wine. It has a potent antioxidant effect related to hydrogen donation, and the ability to ...
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Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB
Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A. (2019)Background: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in ...
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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
Ortiz-Manrique, Macarena; Valenzuela, Rodrigo; Rincón-Cervera, Miguel Ángel; Echeverría, Francisca; Barrera, Cynthia; Espinosa, Alejandra; Hernández-Rodas, María Catalina; Valenzuela, Alfonso; Videla, Luis A. (2018)Objectives: Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, ...
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Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2
Echeverría, Francisca; Valenzuela, Rodrigo; Espinosa, Alejandra; Bustamante, Andrés; Álvarez, Daniela; Gonzalez-Mañan, Daniel; Ortiz, Macarena; Soto-Alarcon, Sandra; Videla, Luis A. (2019)High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic ...
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Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration
Ortiz, Macarena; Soto-Alarcón, Sandra A.; Orellana, Paula; Espinosa, Alejandra; Campos, Cristian; López-Arana, Sandra; Rincón-Cervera, Miguel Ángel; Illesca, Paola; Valenzuela, Rodrigo; Videla, Luis A. (2020)Objective: Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative stress and mitochondrial dysfunction, which can be eluded by the co-administration of the lipid metabolism modulator docosahexaenoic ...
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Targeting n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease
Valenzuela, Rodrigo; Ortiz, Macarena; Hernández-Rodas, María Catalina; Echeverría, Francisca; Videla, Luis A. (2020)Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...
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Thyroid hormone-induced cytosol-to-nuclear translocation of rat liver Nrf2 is dependent on Kupffer cell functioning
Videla, Luis A.; Cornejo, Pamela; Romanque, Pamela; Santibáñez, Catherine; Castillo-Montecinos, Iván; Vargas, Romina (2012)L-3,3 ,5-triiodothyronine (T3) administration upregulates nuclear factor-E2-related factor 2 (Nrf2) in rat liver, which is redoxsensitive transcription factor mediating cytoprotection. In this work, we studied the role of ...