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Mostrando publicaciones 1-5 de 5
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Antidepressant-relevant behavioral and synaptic molecular effects of long-term fasudil treatment in chronically stressed male rats
Román-Albasini, Luciano; Díaz-Véliz, Gabriela; Olave, Felipe A.; Aguayo, Felipe; García-Rojo, Gonzalo; Corrales, Wladimir; Silva, Juan P.; Ávalos, Ana; Rojas, Paulina S.; Aliaga-Rojas, Esteban; Fiedler, Jenny L. (2020)Several lines of evidence suggest that antidepressant drugs may act by modulating neuroplasticity pathways in key brain areas like the hippocampus. We have reported that chronic treatment with fasudil, a Rho-associated ...
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Chronic stress triggers expression of immediate early genes and differentially affects the expression of AMPA and NMDA subunits in dorsal and ventral hippocampus of rats
Aliaga-Rojas, Esteban; Pacheco, Aníbal; Aguayo, Felipe I.; Muñoz, Mauricio; García-Rojo, Gonzalo; Olave, Felipe A.; Parra-Fiedler, Nicolás; García-Pérez, Alexandra; Tejos-Bravo, Macarena; Rojas, Paulina S.; Parra, Claudio S.; Fiedler, Jenny L. (2017)Previous studies in rats have demonstrated that chronic restraint stress triggers anhedonia, depressive-like behaviors, anxiety and a reduction in dendritic spine density in hippocampal neurons. In this study, we compared ...
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Deletion of hippocampal Glucocorticoid receptors unveils sex-biased microRNA expression and neuronal morphology alterations in mice
Tejos-Bravo, Macarena; Oakley, Robert H.; Whirledge, Shannon D.; Corrales, Wladimir; Silva, Juan P.; García-Rojo, Gonzalo; Toledo, Jorge; Sanchez, Wendy; Román-Albasini, Luciano; Aliaga-Rojas, Esteban; Aguayo, Felipe; Olave, Felipe A.; Marcaja-Coutinho, Vinicius; Cidlowski, John A.; Fiedler, Jenny L. (2021)Sex differences in the brain have prompted many researchers to investigate the underlying molecular actors, such as the glucocorticoid receptor (GR). This nuclear receptor controls gene expression, including microRNAs ...
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Hippocampal memory recovery after acute stress: A behavioral, morphological and molecular study
Aguayo, Felipe I.; Tejos-Bravo, Macarena; Díaz-Véliz, Gabriela; Pacheco, Aníbal; García-Rojo, Gonzalo; Corrales, Wladimir; Olave, Felipe A.; Aliaga-Rojas, Esteban; Ulloa, José L.; Avalos, Ana M.; Román-Albasini, Luciano; Rojas, Paulina S.; Fiedler, Jenny L. (2018)Several studies have shown that a single exposure to stress may improve or impair learning and memory processes, depending on the timing in which the stress event occurs with relation to the acquisition phase. However, to ...
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Sex-dependent changes of miRNA levels in the hippocampus of adrenalectomized rats following acute corticosterone administration
Corrales, Wladimir; Silva, Juan P.; Parra, Claudio S.; Olave, Felipe A.; Aguayo, Felipe; Román-Albasini, Luciano; Aliaga-Rojas, Esteban; Venegas-Zamora, Leslye; Avalos, Ana M.; Rojas, P.S.; Marcaja-Coutinho, Vinicius; Oakley, Robert H.; Cidlowski, John A.; Fiedler, Jenny L. (2021)We explored sex-biased effects of the primary stress glucocorticoid hormone corticosterone on the miRNA expression profile in the rat hippocampus. Adult adrenalectomized (ADX) female and male rats received a single ...