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A journey from molecule to physiology and in silico tools for drug discovery targeting the transient receptor potential vanilloid type 1 (TRPV1) channel
Amaya-Rodriguez, Cesar A.; Carvajal-Zamorano, Karina; Bustos, Daniel; Alegría-Arcos, Melissa; Castillo, Karen (2023)The heat and capsaicin receptor TRPV1 channel is widely expressed in nerve terminals of dorsal root ganglia (DRGs) and trigeminal ganglia innervating the body and face, respectively, as well as in other tissues and organs ...
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Effects of interleukin-1β in glycinergic transmission at the central amygdala
Solorza, Jocelyn; Oliva, Carolina A.; Castillo, Karen; Amestica, Gabriela; Maldifassi, María Constanza; López-Cortés, Xaviera A.; Barra, Rafael; Stehberg, Jimmy; Piesche, Matthias; Sáez-Briones, Patricio; González, Wendy; Arenas-Salinas, Mauricio; Mariqueo, Trinidad A. (2021)Interleukin-1β (IL-1β) is an important cytokine that modulates peripheral and central pain sensitization at the spinal level. Among its effects, it increases spinal cord excitability by reducing inhibitory Glycinergic and ...
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The bisphosphonate zoledronic acid is a TRPV1 channel inhibitor
Castillo, Karen; Duarte, Yorley; Segura, Ignacio A.; Tricarico, Domenico; Chavez, Andres; Latorre, Ramón; Meza, Rodrigo; Ancaten, Carlos; Carvajal-Zamorano, Karina; Scala, Rosa (2023)The heat and capsaicin sensor, the transient receptor potential vanilloid type 1 (TRPV1) channel, is critically involved in pain sensation. Using compounds that activate TRPV1, such as capsaicin (CAP), produces analgesic ...