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Mostrando publicaciones 1-19 de 19
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Adding traditional and emerging biomarkers for risk assessment in secondary prevention: a prospective cohort study of 20 656 patients with cardiovascular disease
Rochmawati, Ike Dhiah; Deo, Salil; Lees, Jennifer; Mark, Patrick B.; Sattar, Naveed; Celis-Morales, Carlos; Pell, Jill P.; Welsh, Paul; Ho, Frederick K. (2025)Aims This study aims to explore whether conventional and emerging biomarkers could improve risk discrimination and calibration in the secondary prevention of recurrent atherosclerotic cardiovascular disease (ASCVD), based ...
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Alzheimer's disease susceptibility gene Apolipoprotein E (APOE) and blood biomarkers in UK Biobank (N = 395,769)
Ferguson, Amy C.; Tank, Rachana; Lyall, Laura M.; Ward, Joey; Celis-Morales, Carlos; Strawbridge, Rona; Ho, Frederick; Whelan, Christopher D.; Gill, Jason M.R.; Welsh, Paul; Anderson, Jana J.; Mark, Patrick B.; Mackay, Daniel; Smith, Daniel J.; Pell, J.P.; Cavanagh, Jonathan; Sattar, Naveed; Lyall, Donald (2020)Background: Alzheimer's disease (AD) is a neurodegenerative condition where the underlying etiology is still unclear. Investigating the potential influence of apolipoprotein E (APOE), a major genetic risk factor, on common ...
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Anxiety disorder, depression and coronary artery disease: associations and modification by genetic susceptibility
Nakada, Shinya; Ward, Joey; Strawbridge, Rona J.; Welsh, Paul; Celis-Morales, Carlos; Ho, Frederick K.; Pell, Jill P. (2025)Background Associations of anxiety disorder and depression with coronary artery disease (CAD) are heterogeneous between populations. This study investigated how genetic susceptibility to CAD alters these associations with ...
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Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants
Zhou, Ziyi; Macpherson, John; Gray, S.R.; Gill, Jason M.R.; Welsh, Paul; Celis-Morales, Carlos; Sattar, Naveed; Pell, J.P.; Ho, Frederick (2021)Aims/hypothesis: People with obesity and a normal metabolic profile are sometimes referred to as having ‘metabolically healthy obesity’ (MHO). However, whether this group of individuals are actually ‘healthy’ is uncertain. ...
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Association between device-measured physical activity and incident heart failure: a prospective cohort study of 94 739 uk biobank participants
Ho, Frederick; Zhou, Ziyi; Petermann-Rocha, Fanny; Para-Soto, Solange; Boonpor, Jirapitcha; Welsh, Paul; Gill, Jason M.R.; Gray, S.R.; Sattar, Naveed; Pell, J.P.; Celis-Morales, Carlos (2022)Background: Studies of objectively measured physical activity (PA) have investigated acute cardiovascular outcomes but not heart failure (HF), an emerging chronic condition. This study aimed to investigate the dose-response ...
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Associations and predictive performance of 11 anthropometric measures with incident type 2 diabetes: a prospective cohort study from the UK Biobank
Boonpor, Jirapitcha; Parra‑Soto, Solange; Talebi, Atefeh; Zhou, Ziyi; Carrasco-Marin, Fernanda; Petermann-Rocha, Fanny; Welsh, Paul; Pell, J.P.; Sattar, Naveed; Gill, Jason M.R.; Gray, S.R.; Celis-Morales, Carlos; Ho, Frederick (2023)Objective The study aim was to investigate associations of 11 anthropometric measures with incident type 2 diabetes and compare their predictive performance. Methods This prospective cohort study included 161,127 White ...
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Associations between grip strength and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
Boonpor, Jirapitcha; Parra, Solange; Petermann-Rocha, Fanny; Ferrari, Gerson Luis de Moraes; Welsh, Paul; Pell, J.P.; Sattar, Naveed; Gill, Jason M.R.; Ho, Frederick; Gray, S.R.; Celis-Morales, Carlos (2021)Introduction: Grip strength has been associated with chronic diseases and mortality. However, current evidence of the association between grip strength and incident type 2 diabetes mellitus (T2DM) is controversial. The aim ...
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Associations of fat and carbohydrate intake with cardiovascular disease and mortality: prospective cohort study of UK Biobank participants
Ho, Frederick; Gray, S.R.; Welsh, Paul; Petermann-Rocha, Fanny; Foster, Hamish M. E.; Waddell, Heather; Anderson, Jana J.; Lyall, Donald; Sattar, Naveed; Gill, Jason M.R.; Mathers, John; Pell, J.P.; Celis-Morales, Carlos (2020)Objective: To investigate the association of macronutrient intake with all cause mortality and cardiovascular disease (CVD), and the implications for dietary advice. Design: Prospective population based study. Setting: ...
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Comment on “Change in physical activity and its association with decline in kidney function: a UK biobank-based cohort study” by Liu et al.—The authors' reply
Liu, Qiaoling; Celis-Morales, Carlos; Lees, Jennifer S.; Sattar, Naveed; Ho, Frederick K.; Pell, Jill P.; Mark, Patrick B.; Welsh, Paul (2025) -
Comment on “change in physical activity and its association with decline in kidney function: A UK biobank-based cohort study” by Liu et al.—The authors' reply
Liu, Qiaoling; Celis-Morales, Carlos; Lees, Jennifer S.; Sattar, Naveed; Ho, Frederick K.; Pell, Jill P.; Mark, Patrick B.; Welsh, Paul (2025) -
Comparison of two different frailty measurements and risk of hospitalisation or death from COVID-19: findings from UK Biobank
Petermann-Rocha, Fanny; Hanlon, Peter; Gray, S.R.; Welsh, Paul; Gill, Jason M.R.; Foster, Hamish M. E.; Katikireddi, Vittal S.; Lyall, Donald; Mackay, Daniel; O’Donnell, Catherine A.; Sattar, Naveed; Nicholl, Barbara I.; Pell, J.P.; Jani, Bhautesh D.; Ho, Frederick; Mair, Frances S.; Celis-Morales, Carlos (2020)Background. Frailty has been associated with worse prognosis following COVID-19 infection. While several studies have reported the association between frailty and COVID-19 mortality or length of hospital stay, there have ...
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Discordance between cystatin C-based and creatinine-based estimated glomerular filtration rate and health outcomes in adults: a systematic review and meta-analysis
Liu, Qiaoling; Welsh, Paul; Celis-Morales, Carlos; Ho, Frederick K.; Lees, Jennifer S.; Mark, Patrick B. (2025)Background The intra-individual difference in cystatin C–based and creatinine-based estimated glomerular filtration rate (eGFRcys and eGFRcr, respectively), i.e. eGFR discordance, has recently been demonstrated to have ...
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Dose–response relationship between device-measured physical activity and incident type 2 diabetes: findings from the UK Biobank prospective cohort study
Boonpor, Jirapitcha; Parra‑Soto, Solange; Petermann-Rocha, Fanny; Lynskey, Nathan; Cabanas-Sánchez, Verónica; Sattar, Naveed; Gill, Jason M.R.; Welsh, Paul; Pell, J.P.; Gray, S.R.; Ho, Frederick; Celis-Morales, Carlos (2023)Background Most studies investigating the association between physical activity (PA) and the risk of type 2 diabetes are derived from self-reported questionnaires, with limited evidence using device-based measurements. ...
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Effect of exercise on kidney-relevant biomarkers in the general population: a systematic review and meta-analysis
Liu, Qiaoling; Celis-Morales, Carlos; Lees, Jennifer; Mark, Patrick B.; Welsh, Paul (2025)Objective Physical activity (PA) has been generally recognised as beneficial for health. The effect of a change in PA on kidney biomarkers in healthy individuals without kidney disease remains unclear. This manuscript ...
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Identifying the biomarker profile of pre-frail and frail people: a cross-sectional analysis from UK biobank
Chu, Wenying; Lynskey, Nathan; Iain-Ross, James; Pell, J.P.; Sattar, Naveed; Ho, Frederick; Welsh, Paul; Celis-Morales, Carlos; Petermann-Rocha, Fanny (2023)Objective: This study aimed to compare the biomarker profile of pre-frail and frail adults in the UK Biobank cohort by sex. Methods: In total, 202,537 participants (67.8% women, aged 37 to 73 years) were included in this ...
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Physical capability markers used to define sarcopenia and their association with cardiovascular and respiratory outcomes and all-cause mortality: a prospective study from UK biobank
Petermann-Rocha, Fanny; Ho, Frederick; Welsh, Paul; Mackay, Daniel; Brown, Rosemary E.; Gill, Jason M.R.; Sattar, Naveed; Gray, S.R.; Pell, J.P.; Celis-Morales, Carlos (2020)Introduction: It is unclear what combinations of physical capability markers used to define sarcopenia have the strongest associations with health outcomes. Aim: To compare the associations between different combinations ...
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Refining PREVENT prediction models for 10-year risk of cardiovascular disease using measures of anxiety and depression
Nakada, Shinya; Welsh, Paul; Celis-Morales, Carlos; Pell, Jill P.; Ho, Frederick K. (2025)Background: Anxiety and depression are associated with cardiovascular disease (CVD). We aimed to investigate whether adding measures of anxiety and depression to the American Heart Association Predicting Risk of Cardiovascular ...
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Understanding how much TV is too much: a nonlinear analysis of the association between television viewing time and adverse health outcomes
Foster, Hamish M. E.; Ho, Frederick; Sattar, Naveed; Welsh, Paul; Pell, J.P.; Gill, Jason M.R.; Gray, S.R.; Celis-Morales, Carlos (2020)Objective: To inform potential guideline development, we investigated nonlinear associations between television viewing time (TV time) and adverse health outcomes. Methods: From 2006 to 2010, 490,966 UK Biobank participants, ...
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Vegetarians, fish, poultry, and meat-eaters: Who has higher risk of cardiovascular disease incidence and mortality? A prospective study from UK Biobank
Petermann-Rocha, Fanny; Parra, Solange; Gray, S.R.; Anderson, Jana J.; Welsh, Paul; Gill, Jason M.R.; Ho, Frederick; Celis-Morales, Carlos; Pell, J.P.; Sattar, Naveed (2021)Aims: To compare the incidence and mortality risk for cardiovascular diseases (CVD) [CVD and also ischaemic heart disease (IHD), myocardial infarction (MI), stroke, and heart failure (HF)] among people with different types ...