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Attenuation of high-fat diet-induced rat liver oxidative stress and steatosis by combined hydroxytyrosol- (HT-) eicosapentaenoic acid supplementation mainly relies on HT
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Soto-Alarcon, Sandra; Muñoz, Patricio; Corbari, Alicia; Videla, Luis A. (2018)Pharmacological therapy for nonalcoholic fatty liver disease (NAFLD) is not approved at the present time. For this purpose, the effect of combined eicosapentaenoic acid (EPA; 50 mg/kg/day) modulating hepatic lipid metabolism ...
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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
Soto-Alarcon, Sandra; Ortiz, Macarena; Orellana, Paula; Echeverría, Francisca; Bustamante, Andrés; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañán, Daniel; Valenzuela, Rodrigo; Videla, Luis A. (2019)Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ...
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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañan, Daniel; Videla, Luis A. (2019)High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the ...
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Hydroxytyrosol and Cytoprotection: A projection for clinical interventions
Ortiz-Manrique, Macarena; Echeverría, Francisca; Valenzuela, Rodrigo; Videla, Luis A. (2017)Hydroxytyrosol (HT) ((3,4-Dihydroxyphenyl)ethanol) is a polyphenol mainly present in extra virgin olive oil (EVOO) but also in red wine. It has a potent antioxidant effect related to hydrogen donation, and the ability to ...
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Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB
Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A. (2019)Background: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in ...
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Iron-induced pro-oxidant and pro-lipogenic responses in relation to impaired synthesis and accretion of long-chain polyunsaturated fatty acids in rat hepatic and extrahepatic tissues
Ortiz-Manrique, Macarena; Valenzuela, Rodrigo; Rincón-Cervera, Miguel Ángel; Echeverría, Francisca; Barrera, Cynthia; Espinosa, Alejandra; Hernández-Rodas, María Catalina; Valenzuela, Alfonso; Videla, Luis A. (2018)Objectives: Iron is involved in processes involving oxygen transfer and utilization. Excess iron is linked to cardiovascular diseases and some types of cancer. Iron overload is associated with oxidative stress development, ...
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Reduction of high-fat diet-induced liver proinflammatory state by eicosapentaenoic acid plus hydroxytyrosol supplementation: involvement of resolvins RvE1/2 and RvD1/2
Echeverría, Francisca; Valenzuela, Rodrigo; Espinosa, Alejandra; Bustamante, Andrés; Álvarez, Daniela; Gonzalez-Mañan, Daniel; Ortiz, Macarena; Soto-Alarcon, Sandra; Videla, Luis A. (2019)High-fat diet (HFD)-fed mice show obesity with development of liver steatosis and a proinflammatory state without establishing an inflammatory reaction. The aim of this work was to assess the hypothesis that eicosapentaenoic ...
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Targeting n-3 polyunsaturated fatty acids in non-alcoholic fatty liver disease
Valenzuela, Rodrigo; Ortiz, Macarena; Hernández-Rodas, María Catalina; Echeverría, Francisca; Videla, Luis A. (2020)Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is characterized by abnormal hepatic accumulation of triacylglycerides in the absence of alcohol consumption, in association with Oxidative Stress (OS), a pro-inflammatory ...