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Mostrando publicaciones 1-6 de 6

  • 659 Blocking cytokine IL-1 with anakinra for the prevention of cytokine release syndrome in COVID-19 

    Soule, Erik; Williams, Jason; Piesche, Matthias (2020)
    Background: The novel coronavirus, known as SARS-CoV-2, or COVID-19 became a pandemic in early 2020, causing significant human suffering and economic woes globally. The pathophysiology of acute respiratory failure may be ...

  • Adipose tissue macrophages as a therapeutic target in obesity-associated diseases 

    Herrada, Andrés A.; Olate-Briones, Alexandra; Rojas, Armando ORCID; Liu, Chaohong; Escobedo, Noelia; Piesche, Matthias (2021)
    Obesity is an increasing problem in developed and developing countries. Individuals with obesity have a higher risk of several diseases, such as cardiovascular disease, increased risk of insulin resistance, type 2 diabetes, ...

  • Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future antileukotriene therapy 

    Roos, Jessica; Peters, Marcus; Maucher, Isabelle V.; Kühn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Sommer, Benita; Urbschat, Anja; Piesche, Matthias; Vogel, Anja; Proschak, Ewgenij; Blöcher, René; Buscató, Estella; Häfner, Ann-Kathrin; Matrone, Carmela; Werz, Oliver; Heidler, Juliana; Wittig, Ilka; Angioni, Carlo; Geisslinger, Gerd; Parnham, Michael J.; Zacharowski, Kai D.; Steinhilber, Dieter; Maier, Thorsten J. (2018)
    Aims: 5-Lipoxygenase (5-LO) is the key enzyme of leukotriene (LT) biosynthesis and is critically involved in a number of inflammatory diseases such as arthritis, gout, bronchial asthma, atherosclerosis, and cancer. Because ...

  • Effects of interleukin-1β in glycinergic transmission at the central amygdala 

    Solorza, Jocelyn; Oliva, Carolina A.; Castillo, Karen; Amestica, Gabriela; Maldifassi, María Constanza; López-Cortés, Xaviera A.; Barra, Rafael; Stehberg, Jimmy; Piesche, Matthias; Sáez-Briones, Patricio; González, Wendy; Arenas-Salinas, Mauricio; Mariqueo, Trinidad A. (2021)
    Interleukin-1β (IL-1β) is an important cytokine that modulates peripheral and central pain sensitization at the spinal level. Among its effects, it increases spinal cord excitability by reducing inhibitory Glycinergic and ...

  • RGD-binding integrins and TGF-β in SARS-CoV-2 infections – novel targets to treat COVID-19 patients? 

    Carvacho-Contreras, Ingrid; Piesche, Matthias (2021)
    The new coronavirus SARS-CoV-2 is a global pandemic and a severe public health crisis. SARS-CoV-2 is highly contagious and shows high mortality rates, especially in elderly and patients with pre-existing medical conditions. ...

  • The emerging therapeutic potential of nitro fatty acids and other michael acceptor-containing drugs for the treatment of inflammation and cancer 

    Piesche, Matthias; Roos, Jessica; Kühn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Maucher, Isabelle V.; Awad, Omar; Matrone, Carmela; Comerma-Steffensen, Simon G.; Manolikakes, Georg; Heinicke, Ulrike; Zacharowski, Kai D.; Steinhilber, Dieter; Maier, Thorsten J. (2020)
    Nitro fatty acids (NFAs) are endogenously generated lipid mediators deriving from reactions of unsaturated electrophilic fatty acids with reactive nitrogen species. Furthermore, Mediterranean diets can be a source of NFA. ...