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Main methods and tools for peptide development based on protein-protein interactions (PPIs)
Baeza, Javiera; Bedoya, Mauricio; Cruz, Pablo; Ojeda, Paola; Adasme-Carreño, Francisco; Cerda, Oscar; González, Wendy (2025)Protein-protein interactions (PPIs) regulate essential physiological and pathological processes. Due to their large and shallow binding surfaces, PPIs are often considered challenging drug targets for small molecules. ...
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Pharmaceutical applications of cyclotides
Ojeda, Paola G.; Cardoso, Marlon H.; Franco, Octávio L. (2019)Cyclotides are cyclic peptides, present in several plant families, that show diverse biological properties. Structurally, cyclotides share a distinctive head-to-tail circular knotted topology of three disulfide bonds. This ...