• HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism 

    Rojas, Armando ORCID; Delgado-López, Fernando; Pérez-Castro, Ramón; González-Bonet, Ileana; Romero, Jacqueline; Rojas, Israel; Araya, Paulina; Morales-Mejías, Erik; Llano, Jorge; Añazco-Oyarzún, Carolina (2016)
    The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...

  • M2 macrophages do not fly into a “RAGE” 

    Rojas, Armando ORCID; Araya, Paulina; Añazco-Oyarzún, Carolina (2017)
    Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...

  • Role of multiligand/RAGE axis in platelet activation 

    Rojas, Armando ORCID; Fuentes, Eduardo; Palomo, Iván (2014)
    In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...