Now showing items 1-3 of 3

  • HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism 

    Rojas, Armando ORCID; Delgado-López, Fernando; Pérez-Castro, Ramón; González-Bonet, Ileana; Romero, Jacqueline; Rojas, Israel; Araya, Paulina; Morales-Mejías, Erik; Llano, Jorge; Añazco-Oyarzún, Carolina (2016)
    The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...

  • M2 macrophages do not fly into a “RAGE” 

    Rojas, Armando ORCID; Araya, Paulina; Añazco-Oyarzún, Carolina (2017)
    Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...

  • Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages 

    Rojas, Armando ORCID; Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; González-Bonet, Ileana; Añazco-Oyarzún, Carolina; Pérez-Castro, Ramón (2018)
    Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...