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Listar por materia "Nitrosylation"

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  • Drug-mediated intracellular donation of nitric oxide potently inhibits 5-lipoxygenase: a possible key to future antileukotriene therapy 

    Roos, Jessica; Peters, Marcus; Maucher, Isabelle V.; Kühn, Benjamin; Fettel, Jasmin; Hellmuth, Nadine; Brat, Camilla; Sommer, Benita; Urbschat, Anja; Piesche, Matthias; Vogel, Anja; Proschak, Ewgenij; Blöcher, René; Buscató, Estella; Häfner, Ann-Kathrin; Matrone, Carmela; Werz, Oliver; Heidler, Juliana; Wittig, Ilka; Angioni, Carlo; Geisslinger, Gerd; Parnham, Michael J.; Zacharowski, Kai D.; Steinhilber, Dieter; Maier, Thorsten J. (2018)
    Aims: 5-Lipoxygenase (5-LO) is the key enzyme of leukotriene (LT) biosynthesis and is critically involved in a number of inflammatory diseases such as arthritis, gout, bronchial asthma, atherosclerosis, and cancer. Because ...