Browsing by Subject "RAGE"
Now showing items 1-6 of 6
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Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
Rojas, Armando
; ; (2016)
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...
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Dietary advanced glycation end products and their role in health and disease
Rojas, Armando; ; ; ; ; ; ; ; ; ; ; ; ; ; ; (2015)
Over the past 2 decades there has been increasing evidence supporting an important contribution from food-derived advanced glycation end products (AGEs) to the body pool of AGEs and therefore increased oxidative stress and ...
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Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
Rojas, Armando; ; ; (2018)
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
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NF-κB signaling pathway as target for antiplatelet activity
Rojas, Armando; ; (2016)
In different nucleated cells, NF-κB has long been considered a prototypical proinflammatory signaling pathway with the expression of proinflammatory genes. Although platelets lack a nucleus, a number of functional ...
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Role of multiligand/RAGE axis in platelet activation
Rojas, Armando; ; (2014)
In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end ...
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The immunobiology of the receptor of advanced glycation end-products: Trends and challenges
; ; ; ; Rojas, Armando (2013)
Pattern-recognition receptors have been highly conserved in evolution. They recognize danger signals including both pathogen- and damage-associated molecular patterns, also known as alarmins. Several signaling pathways ...