Browsing by Subject "Tumor microenvironment"
Now showing items 1-5 of 5
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Cross-talk between platelet and tumor microenvironment: Role of multiligand/RAGE axis in platelet activation
Rojas, Armando
; ; (2016)
While platelets are well known to play a central role in hemostasis and thrombosis, there is emerging experimental evidence to suggest that they also mediate tumor cell growth, angiogenesis and metastasis. The receptor for ...
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Extracellular matrix glycation and receptor for advanced glycation end-products activation: A missing piece in the puzzle of the association between diabetes and cancer
Rojas, Armando; ; ; (2018)
A growing body of epidemiologic evidence suggests that people with diabetes are at a significantly higher risk of many forms of cancer. However, the molecular mechanisms underlying this association are not fully understood. ...
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Gastric tumor microenvironment
Rojas, Armando; ; ; (2020)
A compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided ...
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M2 macrophages do not fly into a “RAGE”
Rojas, Armando; ; (2017)
Tumor-associated macrophages (TAMs) are key elements in orchestrating host responses inside tumor stroma. This population may undergo a polarized activation process, thus rendering a heterogeneous spectrum of phenotypes, ...
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Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Rojas, Armando; ; ; ; ; ; (2018)
Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...