Listar Artículos Científicos por autor
Mostrando publicaciones 1-17 de 17
-
Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling
Wernstedt Asterholm, Ingrid; Tao, Caroline; Morley, Thomas S.; Wang, Qiong A.; Delgado-López, Fernando; Wang, Zhao V.; Scherer, Philipp E. (2014)Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that ...
-
Adipose tissue, non-communicable diseases, and physical exercise: an imperfect triangle
Monsalve, Francisco A.; Delgado-López, Fernando; Fernández-Tapia, Barbra; González, Daniel R. (2023)The study of adipose tissue has received considerable attention due to its importance not just in maintaining body energy homeostasis but also in playing a role in a number of other physio logical processes. Beyond storing ...
-
Breast cancer and environmental contamination: A real connection?
Delgado-López, Fernando; Zamora-León, Pilar (2018)Breast cancer is the most prevalent cancer among women and the second cause of cancer-related death in the world. This review describes the effects of bisphenol A, phthalates, and parabens, important environmental chemicals ...
-
Cytotoxic effect of geranylphenol derivatives in the human breast cancer cell line MDA-MB-231 and gastric cancer cell line MKN74
Espinoza, Luis; Taborga, Lautaro; Araya, Paulina; Delgado-López, Fernando; Zamora-León, Pilar (2020)Background: Previous studies have demonstrated that geranyl metabolites, found mainly in marine organisms, exhibit interesting antimicrobial and antifungal activities. In addition, linear geranyl derivatives have been ...
-
Differential expression of two-pore domain potassium channels in rat cerebellar granule neurons
Burgos, Paulina; Zúñiga, Rafael; Domínguez, Pedro; Delgado-López, Fernando; Plant, Leigh D.; Zúñiga, Leandro (2014)Two pore domain potassium (K2P) channels are mostly present in the central nervous system (CNS) where they play important roles in modulating neuronal excitability. K2P channels give rise to background K+ currents (IKSO) ...
-
HMGB1 decreases CCR-2 expression and migration of M2 macrophages under hypoxia
Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; Gonzalez, Ileana; Añazco-Oyarzún, Carolina; Perez, Ramón; Rojas, Armando (2019)Objective: The hypoxic milieu at tumor microenvironment is able to drive the behavior of infiltrating tumor cells. Considering that hypoxia-mediated HMGB1 release is known to promote tumor growth, as well to enhance the ...
-
HMGB1 enhances the protumoral activities of M2 macrophages by a RAGE-dependent mechanism
Rojas, Armando ; Delgado-López, Fernando; Pérez-Castro, Ramón; González-Bonet, Ileana; Romero, Jacqueline; Rojas, Israel; Araya, Paulina; Morales-Mejías, Erik; Llano, Jorge; Añazco-Oyarzún, Carolina (2016)The monocyte-macrophage lineage shows a high degree of diversity and plasticity. Once they infiltrate tissues,they may acquire two main functional phenotypes, being known as the classically activated type 1 macrophages ...
-
Lysyl oxidase isoforms in gastric cancer
Delgado-López, Fernando; Araya, Paulina; González-Bonet, Ileana; Morales-Mejías, Erik; Pérez-Castro, Ramón; Romero, Jacqueline; Rojas, Armando ; Añazco-Oyarzún, Carolina (2016)Gastric cancer (GC) is the fifth most frequent cancer in the world and shows the highest incidence in Latin America and Asia. An increasing amount of evidence demonstrates that lysyl oxidase isoforms, a group of extracellular ...
-
Peroxisome proliferator-cctivated receptor targets for the treatment of metabolic diseases
Monsalve-Abaca, Francisco; Pyarasani, Radha D.; Delgado-López, Fernando; Moore-Carrasco, Rodrigo (2013)Metabolic syndrome is estimated to affect more than one in five adults, and its prevalence is growing in the adult and pediatric populations. The most widely recognized metabolic risk factors are atherogenic dyslipidemia, ...
-
Polycyclic Aromatic Hydrocarbons and their Association with Breast Cancer
Zamora-León, Pilar; Delgado-López, Fernando (2020)Background and Rationale: Polycyclic aromatic hydrocarbons are a lipophilic group of pollutants that persist in the atmosphere for long periods, constituting a permanent source of exposure for humans. They have been ...
-
RAGE at tumor microenvironment. Looking at tumor-associated macrophages
Delgado-López, Fernando (2015) -
RID: Evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
Monsalve, Francisco A.; Rojas, Armando ; González-Bonet, Ileana; Pérez-Castro, Ramón; Añazco-Oyarzún, Carolina; Romero, Jacqueline; Araya, Paulina; Santos, Leonardo S.; Delgado-López, Fernando (2020)Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
-
RID: evaluation of the possible inhibiting effect of the proinflammatory signaling induced by TNF-α through NF-κβ and AP-1 in two cell lines of breast cancer
Monsalve, Francisco A.; Rojas, Armando ; Gonzalez, Ileana; Perez, Ramón; Añasco, Carolina; Romero, Jacqueline; Araya, Paulina; Santos, Leonardo S.; Delgado-López, Fernando (2020)Receptor internalization and degradation (RID), is a transmembrane protein coded within the E3 region expression cassette of adenoviruses. RID downregulates the cell surface expression of epidermal growth factor receptor ...
-
Skewed signaling through the receptor for advanced glycation end-products alters the proinflammatory profile of tumor-associated macrophages
Rojas, Armando ; Araya, Paulina; Romero, Jacqueline; Delgado-López, Fernando; González-Bonet, Ileana; Añazco-Oyarzún, Carolina; Pérez-Castro, Ramón (2018)Tumors are complex tissues composed of variable amounts of both non-cellular components (matrix proteins) and a multitude of stromal cell types, which are under an active cross-talk with tumor cells. Tumor-associated ...
-
The emerging role of the receptor for advanced glycation end products on innate immunity
Rojas, Armando ; Pérez-Castro, Ramón; González-Bonet, Ileana; Delgado-López, Fernando; Romero, Jacqueline; Rojas, Israel (2014)Cells from innate immune system are activated by the engagement of germ-line encoded patternrecognition receptors (PRRs) in response to the microbial insult. These receptors are able to recognize either the presence of ...
-
The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor
Rojas, Armando ; Delgado-López, Fernando; González-Bonet, Ileana; Pérez-Castro, Ramón; Romero, Jacqueline; Rojas, Israel (2013)Firstly described in 1992, the receptor for advanced glycation end-products has attracted increasing attention due to its diverse ligand repertoire and involvement in several pathophysiological processes associated with ...