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Docosahexaenoic acid and hydroxytyrosol co-administration fully prevents liver steatosis and related parameters in mice subjected to high-fat diet: A molecular approach
Soto-Alarcon, Sandra; Ortiz, Macarena; Orellana, Paula; Echeverría, Francisca; Bustamante, Andrés; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañán, Daniel; Valenzuela, Rodrigo; Videla, Luis A. (2019)Attenuation of high-fat diet (HFD)-induced liver steatosis is accomplished by different nutritional interventions. Considering that the n-3 PUFA docosahexaenoic acid (DHA) modulates lipid metabolism and the antioxidant ...
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High-fat diet induces mouse liver steatosis with a concomitant decline in energy metabolism: attenuation by eicosapentaenoic acid (EPA) or hydroxytyrosol (HT) supplementation and the additive effects upon EPA and HT co-administration
Echeverría, Francisca; Valenzuela, Rodrigo; Bustamante, Andrés; Álvarez, Daniela; Ortiz, Macarena; Espinosa, Alejandra; Illesca, Paola; Gonzalez-Mañan, Daniel; Videla, Luis A. (2019)High-fat-diet (HFD) feeding is associated with liver oxidative stress (OS), n-3 long-chain polyunsaturated fatty acid (n-3 LCPUFA) depletion, hepatic steatosis and mitochondrial dysfunction. Our hypothesis is that the ...
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Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB
Illesca, Paola; Valenzuela, Rodrigo; Espinosa, Alejandra; Echeverría, Francisca; Soto-Alarcon, Sandra; Ortiz, Macarena; Videla, Luis A. (2019)Background: White adipose tissue (WAT) have a relevant metabolic and inflammatory function, in overweight or obesity conditions. In this regard, the WAT under over feeding nutrition present a significant increment in ...
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Suppression of high-fat diet-induced obesity-associated liver mitochondrial dysfunction by docosahexaenoic acid and hydroxytyrosol co-administration
Ortiz, Macarena; Soto-Alarcón, Sandra A.; Orellana, Paula; Espinosa, Alejandra; Campos, Cristian; López-Arana, Sandra; Rincón-Cervera, Miguel Ángel; Illesca, Paola; Valenzuela, Rodrigo; Videla, Luis A. (2020)Objective: Obesity-induced by high-fat diet (HFD) is associated with liver steatosis, oxidative stress and mitochondrial dysfunction, which can be eluded by the co-administration of the lipid metabolism modulator docosahexaenoic ...