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Listar Artículos Científicos por materia "K2P channels"

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  • Brief tutorial to evaluate molecular cavities in large conformational ensembles: a K2P channel study case 

    Bustos, Daniel; Palma, Jonathan M.; Vidal, Maira; González, Wendy; Hernández, Erix W. (2021)
    In structural bioinformatics, computational biology, or any other field where is important to assess cavities, clefts, pores, or grooves in a macromolecular system, it is imperative to perform this evaluation over a ...

  • Differential expression of two-pore domain potassium channels in rat cerebellar granule neurons 

    Burgos, Paulina; Zúñiga, Rafael; Domínguez, Pedro; Delgado-López, Fernando; Plant, Leigh D.; Zúñiga, Leandro (2014)
    Two pore domain potassium (K2P) channels are mostly present in the central nervous system (CNS) where they play important roles in modulating neuronal excitability. K2P channels give rise to background K+ currents (IKSO) ...

  • Elucidating the structural basis of the intracellular pH sensing mechanism of TASK-2 K2P channels 

    Bustos, Daniel; Bedoya, Mauricio; Ramírez, David; Concha, Guierdy; Zúñiga, Leandro; Decher, Niels; Hernández-Rodríguez, Erix W.; Sepúlveda, Francisco V.; Martínez, Leandro; González, Wendy (2020)
    Two-pore domain potassium (K2P) channels maintain the cell’s background conductance by stabilizing the resting membrane potential. They assemble as dimers possessing four transmembrane helices in each subunit. K2P channels ...

  • Rational design, synthesis, and evaluation of novel polypharmacological compounds targeting NaV1.5, KV1.5, and K2P channels for atrial fibrillation 

    Camargo-Ayala, Lorena; Bedoya, Mauricio; Dasí, Albert; Prüser, Merten; Schütte, Sven; Prent-Peñaloza, Luis; Adasme-Carreño, Francisco; Kiper, Aytug K.; Rinné, Susanne; Camargo-Ayala, Paola Andrea; Peña-Martínez, Paula A.; Bueno-Orovio, Alfonso; Varela, Diego; Wiedmann, Felix; Márquez Montesinos, José C. E; Mazola, Yuliet; Venturini, Whitney; Zúñiga, Rafael; Zúñiga, Leandro; Schmidt, Constanze; Rodriguez, Blanca; Ravens, Ursula; Decher, Niels; Gutiérrez, Margarita; González, Wendy (2025)
    Atrial fibrillation (AF) involves electrical remodeling of the atria, with ion channels such as NaV1.5, KV1.5, and TASK-1 playing crucial roles. This study investigates acetamide-based compounds designed as multi-target ...