Role of multiligand/RAGE axis in platelet activation

dc.contributor.author	Rojas, Armando
dc.contributor.author	Fuentes, Eduardo
dc.contributor.author	Palomo, Iván
dc.date.accessioned	2017-11-03T20:19:51Z
dc.date.available	2017-11-03T20:19:51Z
dc.date.issued	2014
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/1104
dc.description.abstract	In the context of plaque progression, platelet hyperactivity associated with hyperlipidemia contributes to the development of a pro-thrombotic state. In this context, it has been demonstrated that advanced glycation end products (AGEs) significantly increases platelet activation and receptor for AGEs (RAGE) expression at the platelet surface membrane. In addition to AGEs, other ligands (S100, HMGB1 and amyloid β, among others) of RAGE have raised particular attention in platelet activation. Therefore, in this article we describe platelet hyperactivity by AGEs via RAGE-independent and RAGE-dependent pathways.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	Thrombosis Research, 133(3), 308-314	es_CL
dc.subject	Platelets	es_CL
dc.subject	RAGE	es_CL
dc.subject	AGEs	es_CL
dc.subject	S100	es_CL
dc.subject	HMGB1	es_CL
dc.title	Role of multiligand/RAGE axis in platelet activation	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Medicina	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.uri	sibib2.ucm.cl:2066/science/article/pii/S0049384813005409	es_CL
dc.ucm.doi	doi.org/10.1016/j.thromres.2013.11.007	es_CL

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