Sarcomere structure: The importance of  desmin protein in muscle atrophy

Marzuca-Nassr, Gabriel; Vitzel, Kaio Fernando; Mancilla-Solorza, Eladio; Márquez, José Luis

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dc.contributor.author	Marzuca-Nassr, Gabriel
dc.contributor.author	Vitzel, Kaio Fernando
dc.contributor.author	Mancilla-Solorza, Eladio
dc.contributor.author	Márquez, José Luis
dc.date.accessioned	2018-07-04T18:40:34Z
dc.date.available	2018-07-04T18:40:34Z
dc.date.issued	2018
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/1844
dc.description.abstract	Knowing the ultrastructure of skeletal muscle is critical to understand how it works under normal situation and the disorders caused by extreme or pathological conditions. Sarcomere is the basic structural unit of striated muscle tissue. An important element of sarcomere architecture are the intermediate filaments, including the desmin protein. Desmin protein contributes to maintenance of cell integrity, efficient transmission of force and mechanochemical signaling within the myocyte. Because of this, desmin protein has constantly been a focus of research that investigates its alterations associated to damage and muscle atrophy under different conditions. The purpose of the following literature review is to describe the basic concepts of muscle ultrastructure, emphasizing the desmin protein role under conditions of muscle disuse atrophy and aging.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	International Journal of Morphology, 36(2), 576-583	es_CL
dc.subject	Sarcomere	es_CL
dc.subject	Desmin	es_CL
dc.subject	Muscle disuse atrophy	es_CL
dc.subject	Hindlimb suspension	es_CL
dc.subject	Aging	es_CL
dc.subject	Intermediate filaments	es_CL
dc.title	Sarcomere structure: The importance of desmin protein in muscle atrophy	es_CL
dc.title.alternative	Estructura de Sarcómera: La importancia de proteína desmina en atrofia muscular	es_CL
dc.type	Article	es_CL
dc.ucm.facultad	Facultad de Ciencias de la Salud	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.indexacion	Scielo	es_CL