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ABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileans

dc.contributor.authorBoekstegers, Felix
dc.contributor.authorMarcelain, Katherine
dc.contributor.authorBarahona-Ponce, Carol
dc.contributor.authorBaez Benavides, Pablo F.
dc.contributor.authorMüller, Bettina
dc.contributor.authorDe Toro, Gonzalo
dc.contributor.authorRetamales, Javier
dc.contributor.authorBarajas, Olga
dc.contributor.authorAhumada, Monica
dc.contributor.authorMorales, Erik
dc.contributor.authorRojas, Armando
dc.contributor.authorSanhueza, Verónica
dc.contributor.authorLoader, Denisse
dc.contributor.authorRivera, María T.
dc.contributor.authorGutiérrez, Lorena
dc.contributor.authorBernal, Giuliano
dc.contributor.authorOrtega, Alejandro
dc.contributor.authorMontalvo, Domingo
dc.contributor.authorPortiño, Sergio
dc.contributor.authorBertrán, María E.
dc.contributor.authorGabler, F.
dc.contributor.authorSpencer, Loreto
dc.contributor.authorOlloquequi, Jordi
dc.contributor.authorGonzález-Silos, Rosa
dc.contributor.authorFischer, Christine
dc.contributor.authorScherer, Dominique
dc.contributor.authorJenab, Mazda
dc.contributor.authorAleksandrova, Krasimira
dc.contributor.authorKatzke, Verena
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorMoradi, Tahereh
dc.contributor.authorFischer, Krista
dc.contributor.authorBossers, Willem
dc.contributor.authorBrenner, Hermann
dc.contributor.authorHveem, Kristian
dc.contributor.authorEklund, Niina
dc.contributor.authorVölker, Uwe
dc.contributor.authorWaldenberger, Melanie
dc.contributor.authorFuentes-Guajardo, Macarena
dc.contributor.authorGonzález-José, Rolando
dc.contributor.authorBedoya, Gabriel
dc.contributor.authorBortolini, María C.
dc.contributor.authorCanizales, Samuel
dc.contributor.authorGallo, Carla
dc.contributor.authorRuiz-Linares, Andres
dc.contributor.authorRothhammer, Francisco
dc.contributor.authorLorenzo-Bermejo, Justo
dc.date.accessioned2020-09-11T13:33:35Z
dc.date.available2020-09-11T13:33:35Z
dc.date.issued2020
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3065
dc.description.abstractBackground: The first large-scale genome-wide association study of gallbladder cancer (GBC) recently identified and validated three susceptibility variants in the ABCB1 and ABCB4 genes for individuals of Indian descent. We investigated whether these variants were also associated with GBC risk in Chileans, who show the highest incidence of GBC worldwide, and in Europeans with a low GBC incidence. Methods: This population-based study analysed genotype data from retrospective Chilean case-control (255 cases, 2042 controls) and prospective European cohort (108 cases, 181 controls) samples consistently with the original publication. Results: Our results confirmed the reported associations for Chileans with similar risk effects. Particularly strong associations (per-allele odds ratios close to 2) were observed for Chileans with high Native American (=Mapuche) ancestry. No associations were noticed for Europeans, but the statistical power was low. Conclusion: Taking full advantage of genetic and ethnic differences in GBC risk may improve the efficiency of current prevention programs.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceCancer epidemiology, 65, 101643es_CL
dc.subjectCancer epidemiologyes_CL
dc.subjectGallbladder canceres_CL
dc.subjectNative American ancestryes_CL
dc.subjectPopulation-specific risk markeres_CL
dc.titleABCB1/4 gallbladder cancer risk variants identified in India also show strong effects in Chileanses_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.uriwww.sciencedirect.com/science/article/pii/S1877782119301535?via%3Dihubes_CL
dc.ucm.doidoi.org/10.1016/j.canep.2019.101643es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
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