Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK biobank

Ho, Frederick; Celis-Morales, Carlos; Gray, S.R.; Petermann-Rocha, Fanny; Lyall, Donald; Mackay, Daniel; Sattar, Naveed; Minnis, Helen; Pell, J.P.

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dc.contributor.author	Ho, Frederick
dc.contributor.author	Celis-Morales, Carlos
dc.contributor.author	Gray, S.R.
dc.contributor.author	Petermann-Rocha, Fanny
dc.contributor.author	Lyall, Donald
dc.contributor.author	Mackay, Daniel
dc.contributor.author	Sattar, Naveed
dc.contributor.author	Minnis, Helen
dc.contributor.author	Pell, J.P.
dc.date.accessioned	2020-10-26T21:09:38Z
dc.date.available	2020-10-26T21:09:38Z
dc.date.issued	2020
dc.identifier.uri	http://repositorio.ucm.cl/handle/ucm/3125
dc.description.abstract	Background: Child maltreatment is associated with cardiovascular disease (CVD), but mediation pathways have not been fully elucidated. The aim of the current study was to determine and quantify the underlying pathways linking child maltreatment and CVD. Methods: We conducted a retrospective cohort study using the UK Biobank. The number and types of child maltreatment, including abuse and neglect, were recalled by the participants. Lifestyle, biological, physical, and mental health factors measured at baseline were explored as potential mediators. Incident CVD was ascertained through record linkage after baseline measurement. Age, sex, ethnicity, area-based deprivation, and education level were adjusted for as confounders. Cox proportional hazard models were conducted to test for associations between child maltreatment and incident CVD. Results: A total of 152,040 participants who completed the child maltreatment assessment were included in the analyses, and one third reported at least one type of child maltreatment. There was a dose-response relationship between the number of maltreatment types and incident CVD. On average, each additional type of child maltreatment was associated with an 11% (95% CI 8–14%, P < 0.0001) increased risk of CVD. The majority (56.2%) of the association was mediated through depressive symptoms, followed by smoking (14.7%), high-density lipoprotein cholesterol (8.7%), and sleep duration (2.4%). Conclusion: Child maltreatment is associated with incident CVD through a combination of mental health, lifestyle, and biological pathways. Therefore, in addition to interventions to reduce the occurrence of child maltreatment, attention should be targeted at promoting healthy lifestyles and preventing, identifying, and treating depression among children and adults who have previously been maltreated.	es_CL
dc.language.iso	en	es_CL
dc.rights	Atribución-NoComercial-SinDerivadas 3.0 Chile	*
dc.rights.uri	http://creativecommons.org/licenses/by-nc-nd/3.0/cl/	*
dc.source	BMC Medicine, 18, 143	es_CL
dc.subject	Child maltreatment	es_CL
dc.subject	Cardiovascular disease	es_CL
dc.subject	Depression	es_CL
dc.subject	Mediation	es_CL
dc.title	Child maltreatment and cardiovascular disease: quantifying mediation pathways using UK biobank	es_CL
dc.type	Article	es_CL
dc.ucm.indexacion	Scopus	es_CL
dc.ucm.indexacion	Isi	es_CL
dc.ucm.doi	doi.org/10.1186/s12916-020-01603-z	es_CL