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dc.contributor.authorFuentes-Contreras, Jorge
dc.contributor.authorArmijo-Olivo, Susan
dc.contributor.authorDa Costa, Bruno
dc.contributor.authorHa, Christine
dc.contributor.authorSaltaji, Humam
dc.contributor.authorArenti, Chiara
dc.contributor.authorNegrini, Stefano
dc.contributor.authorCummings, Greta G.
dc.description.abstractBackground: Sponsorship bias could affect research results to inform decision makers when using the results of these trials. The extent to which sponsorship bias affect results in the field of physical therapy has been unexplored in the literature. Therefore, the main aim of this study was to evaluate the influence of sponsorship bias on the treatment effects of randomized controlled trials in physical therapy area. Methods: This was a meta-epidemiological study. A random sample of randomized controlled trials included in meta-analyses of physical therapy area were identified. Data extraction including assessments of appropriate influence of funders was conducted independently by two reviewers. To determine the association between biases related to sponsorship biases and effect sizes, a two-level analysis was conducted using a meta-meta-analytic approach. Results: We analyzed 393 trials included in 43 meta-analyses. The most common sources of sponsorship for this sample of physical therapy trials were government (n = 205, 52%), followed by academic (n = 44, 11%) and industry (n = 39, 10%). The funding was not declared in a high percentage of the trials (n = 85, 22%). The influence of the trial sponsor was assessed as being appropriate in 246 trials (63%) and considered inappropriate/unclear in 147 (37%) of them. We have moderate evidence to say that trials with inappropriate/unclear influence of funders tended to have on average a larger effect size than those with appropriate influence of funding (effect size = 0.15; 95% confidence interval = −0.03 to 0.33). Conclusions: Based on our sample of physical therapy trials, it seems that most of the trials are funded by either government and academia and a small percentage are funded by the industry. Treatment effect size estimates were on average 0.15 larger in trials with lack of appropriate influence of funders as compared with trials with appropriate influence of funding. Contrarily to other fields, industry funding was relatively small and their influence perhaps less marked. All these results could be explained by the relative youth of the field and/or the absence of clear industry interests. In front of the call for action by the World Health Organization to strengthen rehabilitation in health systems, these results raise the issue of the need of public funding in the field.es_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.sourceAmerican Journal of Physical Medicine & Rehabilitation, 99(10), 909-916es_CL
dc.subjectSponsorship biases_CL
dc.subjectMeta-epidemiological studyes_CL
dc.subjectPhysical therapyes_CL
dc.titleDoes type of sponsorship of randomized controlled trials influence treatment effect size estimates in rehabilitation: a meta-epidemiological studyes_CL
dc.ucm.facultadFacultad de Ciencias de la Saludes_CL

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Atribución-NoComercial-SinDerivadas 3.0 Chile
Except where otherwise noted, this item's license is described as Atribución-NoComercial-SinDerivadas 3.0 Chile