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Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites?
| dc.contributor.author | Parra, Solange | |
| dc.contributor.author | Ho, Frederick | |
| dc.contributor.author | Pell, J.P. | |
| dc.contributor.author | Celis-Morales, Carlos | |
| dc.date.accessioned | 2021-11-18T13:16:43Z | |
| dc.date.available | 2021-11-18T13:16:43Z | |
| dc.date.issued | 2020 | |
| dc.identifier.uri | http://repositorio.ucm.cl/handle/ucm/3478 | |
| dc.description.abstract | Background: Whether the association of height with cancers differs by insulin-like growth factors has not been fully elucidated. Therefore, this study aimed to investigate the sex-specific associations between height and 24 site-specific cancers and to assess whether the association differed by IGF-1. Methods: In total, 414,923 participants from the UK Biobank prospective cohort study were included. The association of height (per 5-cm increment) with incidence and mortality from 24 cancer sites was investigated by using Cox proportional hazard models. Results: The median follow-up was 6.0 years. In men, height was positively associated with incidence risk of all-cause cancer and at five sites (lung, lymphatic, leukaemia, non-Hodgkin lymphoma and melanoma). In women, it was associated with breast, melanoma, lymphatic, non-Hodgkin lymphoma and all-cause cancer. The association was stronger in women than men for all-cause cancer incidence. The strength of the association did not differ by IGF-1 concentration. Conclusions: Adult height was associated with risk of several cancer sites. However, some of these associations were sex-specific. There was no strong evidence to support IGF-1 moderating the association between height and cancer. | es_CL |
| dc.language.iso | en | es_CL |
| dc.rights | Atribución-NoComercial-SinDerivadas 3.0 Chile | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | * |
| dc.source | British Journal of Cancer, 123, 1697-1704 | es_CL |
| dc.title | Does insulin-like growth factor moderate the association between height and risk of cancer at 24 sites? | es_CL |
| dc.type | Article | es_CL |
| dc.ucm.indexacion | Scopus | es_CL |
| dc.ucm.indexacion | Isi | es_CL |
| dc.ucm.uri | nature.com/articles/s41416-020-01059-1 | es_CL |
| dc.ucm.doi | doi.org/10.1038/s41416-020-01059-1 | es_CL |
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