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Gastric tumor microenvironment

dc.contributor.authorRojas, Armando
dc.contributor.authorAraya, Paulina
dc.contributor.authorGonzález-Bonet, Ileana
dc.contributor.authorMorales, Erik
dc.date.accessioned2021-11-18T14:33:14Z
dc.date.available2021-11-18T14:33:14Z
dc.date.issued2020
dc.identifier.urihttp://repositorio.ucm.cl/handle/ucm/3483
dc.description.abstractA compelling body of evidence has demonstrated that gastric cancer has a very particular tumor microenvironment, a signature very suitable to promote tumor progression and metastasis. Recent investigations have provided new insights into the multiple molecular mechanisms, defined by genetic and epigenetic mechanisms, supporting a very active cross talk between the components of the tumor microenvironment and thus defining the fate of tumor progression. In this review, we intend to highlight the role of very active contributors at gastric cancer TME, particularly cancer-associated fibroblasts, bone marrow-derived cells, tumor-associated macrophages, and tumor-infiltrating neutrophils, all of them surrounded by an overtime changing extracellular matrix. In addition, the very active cross talk between the components of the tumor microenvironment, defined by genetic and epigenetic mechanisms, thus defining the fate of tumor progression, is also reviewed.es_CL
dc.language.isoenes_CL
dc.rightsAtribución-NoComercial-SinDerivadas 3.0 Chile*
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
dc.sourceAdvances in Experimental Medicine and Biology, 1226, 23-35es_CL
dc.subjectGastric canceres_CL
dc.subjectChronic inflammationes_CL
dc.subjectTumor microenvironmentes_CL
dc.subjectHelicobacter pylories_CL
dc.subjectTumor-associated macrophageses_CL
dc.subjectCancer-associated fibroblastses_CL
dc.subjectMicroRNAses_CL
dc.subjectExosomeses_CL
dc.subjectExtracellular matrixes_CL
dc.subjectTumor-associated mast cellses_CL
dc.subjectTumor-infiltrating neutrophilses_CL
dc.titleGastric tumor microenvironmentes_CL
dc.typeArticlees_CL
dc.ucm.facultadFacultad de Medicinaes_CL
dc.ucm.indexacionScopuses_CL
dc.ucm.indexacionIsies_CL
dc.ucm.urilink.springer.com/chapter/10.1007%2F978-3-030-36214-0_2es_CL
dc.ucm.doidoi.org/10.1007/978-3-030-36214-0_2es_CL


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Atribución-NoComercial-SinDerivadas 3.0 Chile
Excepto si se señala otra cosa, la licencia de la publicación se describe como Atribución-NoComercial-SinDerivadas 3.0 Chile