Contribution of RAGE axis activation to the association between metabolic syndrome and cancer
Autor
Garay-Sevilla, Ma. Eugenia
Gomez-Ojeda, Armando
González-Bonet, Ileana
Luevano Contreras, Claudia
Fecha
2021Resumen
Far beyond the compelling proofs supporting that the metabolic syndrome represents a risk factor for diabetes and cardiovascular diseases, a growing body of evidence suggests that it is also a risk factor for different types of cancer. However, the involved molecular mechanisms underlying this association are not fully understood, and they have been mainly focused on the individual contributions of each component of the metabolic syndrome such as obesity, hyperglycemia, and high blood pressure to the development of cancer. The Receptor for Advanced Glycation End-products (RAGE) axis activation has emerged as an important contributor to the pathophysiology of many clinical entities, by fueling a chronic inflammatory milieu, and thus supporting an optimal microenvironment to promote tumor growth and progression. In the present review, we intend to highlight that RAGE axis activation is a crosswise element on the potential mechanistic contributions of some relevant components of metabolic syndrome into the association with cancer.
Fuente
Molecular and Cellular Biochemistry, 473(3), 1555-1573Link de Acceso
Click aquí para ver el documentoIdentificador DOI
doi.org/10.1007/s11010-020-04022-zColecciones
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